Cited 86 times in
IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells
DC Field | Value | Language |
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dc.contributor.author | 김범석 | - |
dc.date.accessioned | 2018-11-12T16:40:14Z | - |
dc.date.available | 2018-11-12T16:40:14Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1046-6673 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165148 | - |
dc.description.abstract | Regulatory T cells (Tregs) can suppress immunologic damage in renal ischemia-reperfusion injury (IRI), but the isolation and ex vivo expansion of these cells for clinical application remains challenging. Here, we investigated whether the IL-2/anti-IL-2 complex (IL-2C), a mediator of Treg expansion, can attenuate renal IRI in mice. IL-2C administered before bilateral renal IRI induced Treg expansion in both spleen and kidney, improved renal function, and attenuated histologic renal injury and apoptosis after IRI. Furthermore, IL-2C administration reduced the expression of inflammatory cytokines and attenuated the infiltration of neutrophils and macrophages in renal tissue. Depletion of Tregs with anti-CD25 antibodies abrogated the beneficial effects of IL-2C. However, IL-2C-mediated renal protection was not dependent on either IL-10 or TGF-β. Notably, IL-2C administered after IRI also enhanced Treg expansion in spleen and kidney, increased tubular cell proliferation, improved renal function, and reduced renal fibrosis. In conclusion, these results indicate that IL-2C-induced Treg expansion attenuates acute renal damage and improves renal recovery in vivo, suggesting that IL-2C may be a therapeutic strategy for renal IRI. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | American Society of Nephrology | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Monoclonal/therapeutic use* | - |
dc.subject.MESH | Antigen-Antibody Complex/physiology* | - |
dc.subject.MESH | Cell Differentiation/immunology* | - |
dc.subject.MESH | Drug Evaluation, Preclinical | - |
dc.subject.MESH | Fibrosis | - |
dc.subject.MESH | Interleukin-2/immunology | - |
dc.subject.MESH | Interleukin-2/physiology* | - |
dc.subject.MESH | Kidney/immunology | - |
dc.subject.MESH | Kidney/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Renal Insufficiency/immunology | - |
dc.subject.MESH | Renal Insufficiency/pathology | - |
dc.subject.MESH | Renal Insufficiency/prevention & control* | - |
dc.subject.MESH | Reperfusion Injury/immunology | - |
dc.subject.MESH | Reperfusion Injury/pathology | - |
dc.subject.MESH | Reperfusion Injury/prevention & control* | - |
dc.subject.MESH | T-Lymphocytes, Regulatory/drug effects | - |
dc.subject.MESH | T-Lymphocytes, Regulatory/immunology* | - |
dc.subject.MESH | T-Lymphocytes, Regulatory/pathology | - |
dc.title | IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Myung-Gyu Kim | - |
dc.contributor.googleauthor | Tai Yeon Koo | - |
dc.contributor.googleauthor | Ji-Jing Yan | - |
dc.contributor.googleauthor | Eunwon Lee | - |
dc.contributor.googleauthor | Kyu Hyun Han | - |
dc.contributor.googleauthor | Jong Cheol Jeong | - |
dc.contributor.googleauthor | Han Ro | - |
dc.contributor.googleauthor | Beom Seok Kim | - |
dc.contributor.googleauthor | Sang-Kyung Jo | - |
dc.contributor.googleauthor | Kook Hwan Oh | - |
dc.contributor.googleauthor | Charles D. Surh | - |
dc.contributor.googleauthor | Curie Ahn | - |
dc.contributor.googleauthor | Jaeseok Yang | - |
dc.identifier.doi | 10.1681/ASN.2012080784 | - |
dc.contributor.localId | A00488 | - |
dc.relation.journalcode | J01779 | - |
dc.identifier.eissn | 1533-3450 | - |
dc.identifier.pmid | 23833258 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785269/?report=printable | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | 김범석 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1529 | - |
dc.citation.endPage | 1536 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol.24(10) : 1529-1536, 2013 | - |
dc.identifier.rimsid | 59149 | - |
dc.type.rims | ART | - |
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