Comparison of the optic nerve imaging by time-domain optical coherence tomography and Fourier-domain optical coherence tomography in distinguishing normal eyes from those with glaucoma

Abstract

PURPOSE: To assess agreement in cup-to-disc ratio (CDR) estimation between stereoscopic optic disc photography, time-domain optical coherence tomography (OCT), and Fourier-domain OCT, and to compare the discriminating ability of optic nerve head (ONH) parameters by time-domain OCT and Fourier-domain OCT for glaucoma detection.

METHODS: Participants underwent stereoscopic photography, Stratus OCT (fast optic disc scan), and RTVue-100 (nerve head mapping), at the same visit. Vertical and horizontal CDRs (VCDR and HCDR) from stereoscopic photography were determined by averaging the results from 2 independent glaucoma specialists. VCDR, HCDR, disc area, cup area, rim area, and cup-to-disc area ratio were acquired from the 2 OCTs. Agreement was assessed by intraclass correlation coefficients (ICCs) and Bland-Altman plots. Area under the receiver operator characteristic curve was used to assess the ability of each parameter to detect glaucoma.

RESULTS: A total of 185 eyes were used in final analysis. VCDR and HCDR measurements from RTVue were highest, followed by those from Stratus OCT and stereoscopic photography. CDRs from both OCTs showed excellent agreement with those from stereophotography (ICC, 0.80 to 0.86). Agreement in ONH parameters including CDRs between the 2 OCTs was excellent (ICC, 0.86 to 0.94). There were no statistically significant differences between the ONH parameters from the 2 OCTs with respect to ability to detect glaucoma.

CONCLUSIONS: VCDR and HCDR measurement by time-domain and Fourier-domain OCTs exhibited excellent agreement with each other and agreed equally well with those by stereoscopic photography. The ONH parameters between the 2 OCTs performed similarly in determining glaucoma status.