Cited 7 times in
Clinical outcomes of radiotherapy for spinal cord ependymoma with adverse prognostic features: a single-center study.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 변화경 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 윤홍인 | - |
dc.contributor.author | 이성 | - |
dc.contributor.author | 조재호 | - |
dc.date.accessioned | 2018-10-11T08:56:02Z | - |
dc.date.available | 2018-10-11T08:56:02Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0167-594X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163478 | - |
dc.description.abstract | PURPOSE: This study evaluated the outcomes of radiotherapy (RT) for spinal ependymoma with adverse features, such as incomplete resection or disseminated disease. METHODS: Twenty-five patients underwent RT for spinal cord ependymoma during 1991-2016. Twenty-four patients had gross disease on the pre-RT spinal magnetic resonance images. Six patients (24%) had disseminated disease. The World Health Organization grades were I (12 patients), II (12 patients), and III (1 patient). The RT fields were the tumor bed plus margin in 19 patients (76%), the entire craniospinal axis in 5 patients (20%), and the entire spinal canal with posterior cranial fossa in 1 patient (4%). The median RT dose was 50.4 Gy (range 44.0-59.4 Gy). RESULTS: The median follow-up was 49 months (range 9-321 months), with 5-year overall and progression-free survival rates of 83.7% and 70.8%, respectively. Relative to patients with grade II/III ependymoma, patients with grade I ependymoma had higher 5-year rates of overall survival (100% vs. 69.4%, P = .088) and progression-free survival (100% vs. 42.3%, P = .02). Disease progression was observed in 4 patients who had grade II ependymoma, including 2 of 6 patients with disseminated disease and 2 of 19 patients with localized disease. Twelve patients (48%) exhibited improved neurological function. One patient who underwent craniospinal irradiation developed late hypopituitarism. No other RT-related late toxicities were observed. CONCLUSIONS: Favorable survival outcomes were achieved using RT for spinal ependymoma with adverse prognostic features. Thus, RT may be an effective treatment option when complete tumor removal cannot be achieved. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | JOURNAL OF NEURO-ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Clinical outcomes of radiotherapy for spinal cord ependymoma with adverse prognostic features: a single-center study. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Hwa Kyung Byun | - |
dc.contributor.googleauthor | Seong Yi | - |
dc.contributor.googleauthor | Hong In Yoon | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Jaeho Cho | - |
dc.contributor.googleauthor | Chang-Ok Suh | - |
dc.identifier.doi | 10.1007/s11060-018-2995-1 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A05136 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A04777 | - |
dc.contributor.localId | A02864 | - |
dc.contributor.localId | A03901 | - |
dc.relation.journalcode | J01629 | - |
dc.identifier.eissn | 1573-7373 | - |
dc.identifier.pmid | 30203166 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s11060-018-2995-1 | - |
dc.subject.keyword | Adverse prognostic features | - |
dc.subject.keyword | Incomplete resection | - |
dc.subject.keyword | Radiotherapy | - |
dc.subject.keyword | Spinal cord | - |
dc.subject.keyword | Spinal ependymoma | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Byun, Hwa Kyung | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Yoon, Hong In | - |
dc.contributor.alternativeName | Yi, Seong | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Byun, Hwa Kyung | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Yoon, Hong In | - |
dc.contributor.affiliatedAuthor | Yi, Seong | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.citation.volume | 140 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 649 | - |
dc.citation.endPage | 657 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEURO-ONCOLOGY, Vol.140(3) : 649-657, 2018 | - |
dc.identifier.rimsid | 60427 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.