Cited 35 times in
C-Reactive Protein to Serum Albumin Ratio Is an Independent Predictor of All-Cause Mortality in Patients with ANCA-Associated Vasculitis
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 이상원 | - |
dc.date.accessioned | 2018-10-11T08:53:19Z | - |
dc.date.available | 2018-10-11T08:53:19Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163432 | - |
dc.description.abstract | PURPOSE: We investigated whether C-reactive protein (CRP) to serum albumin ratio (CAR) could be an independent predictor of all-cause mortality in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 170 patients with AAV. We collected clinical and laboratory data. We also examined AAV-related and traditional risk factors of all-cause mortality. To assess the hazard ratios of variables, we performed univariable and multivariable Cox hazard model analyses. RESULTS: The mean age was 55.0 years and 53 patients (31.2%) were male among 170 patients with AAV (88 microscopic polyangiitis, 43 granulomatosis with polyangiitis, and 39 eosinophilic granulomatosis with polyangiitis). ANCA was detected in 129 patients (75.9%). The initial mean CRP and serum albumin were 41.1 (mg/L) and 3.6 (g/dL), and the mean CAR at diagnosis was 14.8. The most common risk factor of mortality was hypertension (42.4%), followed by chronic kidney disease ≥stage 3 (25.9%). Fourteen patients (8.2%) died during the mean follow-up of 56.7 months. In both multivariable Cox hazard model analyses, CAR at diagnosis was identified as an independent predictor of all-cause of mortality comparable to diabetes mellitus (DM). Moreover, patients with CAR ≥10.35 and having DM exhibited a higher frequency of all-cause mortality than those without. CONCLUSION: CAR at diagnosis can be an independent predictor of all-cause mortality, comparable to DM, the conventional risk factor of mortality. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/blood | - |
dc.subject.MESH | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology | - |
dc.subject.MESH | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/mortality* | - |
dc.subject.MESH | Antibodies, Antineutrophil Cytoplasmic/immunology | - |
dc.subject.MESH | C-Reactive Protein/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension/complications | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microscopic Polyangiitis/immunology | - |
dc.subject.MESH | Microscopic Polyangiitis/mortality* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mortality* | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Serum Albumin/metabolism* | - |
dc.subject.MESH | Survival Rate | - |
dc.title | C-Reactive Protein to Serum Albumin Ratio Is an Independent Predictor of All-Cause Mortality in Patients with ANCA-Associated Vasculitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Jae-Seung Moon | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Sang-Kyou Lee | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.identifier.doi | 10.3349/ymj.2018.59.7.865 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A02824 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 30091320 | - |
dc.subject.keyword | Antineutrophil cytoplasmic antibody | - |
dc.subject.keyword | albumin | - |
dc.subject.keyword | c-reactive protein | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | vasculitis | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Ahn, Sung Soo | - |
dc.contributor.alternativeName | Lee, Sang Won | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Ahn, Sung Soo | - |
dc.contributor.affiliatedAuthor | Lee, Sang Won | - |
dc.citation.volume | 59 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 865 | - |
dc.citation.endPage | 871 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.59(7) : 865-871, 2018 | - |
dc.identifier.rimsid | 60382 | - |
dc.type.rims | ART | - |
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