Cited 7 times in
3,4 diaminopyridine for the treatment of myasthenia gravis with electrophysiological patterns of Lambert-Eaton myasthenic syndrome
DC Field | Value | Language |
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dc.contributor.author | 김승민 | - |
dc.date.accessioned | 2018-09-28T09:00:28Z | - |
dc.date.available | 2018-09-28T09:00:28Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0967-5868 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163317 | - |
dc.description.abstract | 3,4-Diaminopyridine (34DAP) is a presynaptic transmission enhancer. Its efficacy for Lambert-Eaton myasthenic syndrome (LEMS) and myasthenia gravis (MG) was demonstrated. However, there are cases sharing the characteristics of both disease and the effect of 34DAP in "gray zone" patients is sparse. Recently, we prescribed 34DAP to five anti-acetylcholine receptor antibody-positive MG patients with electrophysiological LEMS patterns and three LEMS patients, and carefully monitored the responses. Sero-positive MG patients exhibited more favorable responses than LEMS patients. The combination of 34DAP and pyridostigmine resulted in the best outcomes. No significant side effects were recorded during the follow-up period. In conclusion, this study results provide evidence that 34DAP could be effective in sero-positive MG patients with pre-synaptic dysfunction. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Churchill Livingstone | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL NEUROSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 4-Aminopyridine/analogs & derivatives* | - |
dc.subject.MESH | 4-Aminopyridine/therapeutic use | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cholinesterase Inhibitors/therapeutic use | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lambert-Eaton Myasthenic Syndrome/drug therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myasthenia Gravis/drug therapy* | - |
dc.subject.MESH | Potassium Channel Blockers/therapeutic use* | - |
dc.subject.MESH | Pyridostigmine Bromide/therapeutic use | - |
dc.title | 3,4 diaminopyridine for the treatment of myasthenia gravis with electrophysiological patterns of Lambert-Eaton myasthenic syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Moon Kyu Lee | - |
dc.contributor.googleauthor | Il Nam Sunwoo | - |
dc.contributor.googleauthor | Seung Min Kim | - |
dc.identifier.doi | 10.1016/j.jocn.2018.01.024 | - |
dc.contributor.localId | A00653 | - |
dc.relation.journalcode | J01328 | - |
dc.identifier.eissn | 1532-2653 | - |
dc.identifier.pmid | 29402568 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0967586817313322 | - |
dc.subject.keyword | 3,4-Diaminopyridine | - |
dc.subject.keyword | Anti-acetylcholine receptor antibody | - |
dc.subject.keyword | Lambert-Eaton myasthenic syndrome | - |
dc.subject.keyword | Myasthenia gravis | - |
dc.subject.keyword | Treatment | - |
dc.contributor.alternativeName | Kim, Seung Min | - |
dc.contributor.affiliatedAuthor | Kim, Seung Min | - |
dc.citation.volume | 50 | - |
dc.citation.startPage | 194 | - |
dc.citation.endPage | 198 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL NEUROSCIENCE, Vol.50 : 194-198, 2018 | - |
dc.identifier.rimsid | 58718 | - |
dc.type.rims | ART | - |
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