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Microscopic hematuria is a risk factor of incident chronic kidney disease in the Korean general population: a community-based prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.contributor.author | 기연경 | - |
dc.contributor.author | 남기헌 | - |
dc.contributor.author | 박서현 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 안성영 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 윤해룡 | - |
dc.contributor.author | 이미솔 | - |
dc.contributor.author | 지종현 | - |
dc.contributor.author | 차민욱 | - |
dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2018-09-28T08:58:25Z | - |
dc.date.available | 2018-09-28T08:58:25Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1460-2725 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163292 | - |
dc.description.abstract | Background: Although asymptomatic microscopic hematuria (MH) is a common finding in clinical practice, its long-term outcome remains unknown. Aim: This study evaluated the clinical implication of MH in the general population using a large-scale long-term longitudinal cohort database. Methods: This study included 8719 participants from the Korean Genome and Epidemiology Study between 2001 and 2014. MH was defined as ≥5 red blood cells per high-power field in random urinalysis without evidence of pyuria. The primary study outcome measure was incident chronic kidney disease (CKD), defined as estimated glomerular filtration rate <60 ml min-1⋅1.73⋅m-2. Results: During a median follow-up of 11.7 years, CKD occurred in 677 (7.8%) subjects. In Cox regression after adjustment for multiple confounders, subjects with MH had a significantly higher risk of incident CKD than those without [hazard ratio (HR) 1.45, 95% confidence interval (CI) 1.12-1.87; P = 0.005]. Isolated MH without proteinuria was also a risk factor of incident CKD (HR 1.37, 95% CI 1.04-1.79; P = 0.023) and the risk was further increased in MH with concomitant proteinuria (HR 5.41, 95% CI 2.54-11.49; P < 0.001). In propensity score matching analysis after excluding subjects with proteinuria, multi-variable stratified Cox regression analysis revealed that subjects with isolated MH had a significantly higher risk of incident CKD than those without (HR 1.83, 95% CI 1.14-2.94; P = 0.012). Conclusion: The presence of MH is associated with an increased risk of incident CKD in the general population. Therefore, attentive follow-up is warranted in persons with MH for early detection of CKD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | The Association of Physicians of Great Britain and Ireland by the Oxford University Press | - |
dc.relation.isPartOf | QJM-AN INTERNATIONAL JOURNAL OF MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Microscopic hematuria is a risk factor of incident chronic kidney disease in the Korean general population: a community-based prospective cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | H. Kim | - |
dc.contributor.googleauthor | M. Lee | - |
dc.contributor.googleauthor | M.-U. Cha | - |
dc.contributor.googleauthor | K.H. Nam | - |
dc.contributor.googleauthor | S.Y. An | - |
dc.contributor.googleauthor | S. Park | - |
dc.contributor.googleauthor | J.H. Jhee | - |
dc.contributor.googleauthor | H.-R. Yun | - |
dc.contributor.googleauthor | Y.K. Kee | - |
dc.contributor.googleauthor | J.T. Park | - |
dc.contributor.googleauthor | T.-H. Yoo | - |
dc.contributor.googleauthor | S.-W. Kang | - |
dc.contributor.googleauthor | S.H. Han | - |
dc.identifier.doi | 10.1093/qjmed/hcy054 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A00276 | - |
dc.contributor.localId | A01244 | - |
dc.contributor.localId | A01495 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02236 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04617 | - |
dc.contributor.localId | A02771 | - |
dc.contributor.localId | A03970 | - |
dc.contributor.localId | A05046 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J02584 | - |
dc.identifier.eissn | 1460-2393 | - |
dc.identifier.pmid | 29554373 | - |
dc.identifier.url | https://academic.oup.com/qjmed/article/111/6/389/4936876 | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Kee, Youn Kyung | - |
dc.contributor.alternativeName | Nam, Ki Heon | - |
dc.contributor.alternativeName | Park, Seo Hyun | - |
dc.contributor.alternativeName | Park, Jung Tak | - |
dc.contributor.alternativeName | An, Seong Yeong | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Yun, Hae Ryong | - |
dc.contributor.alternativeName | Lee, Mi Sol | - |
dc.contributor.alternativeName | Jhee, Jong Hyun | - |
dc.contributor.alternativeName | Cha, Min Uk | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Kee, Youn Kyung | - |
dc.contributor.affiliatedAuthor | Nam, Ki Heon | - |
dc.contributor.affiliatedAuthor | Park, Seo Hyun | - |
dc.contributor.affiliatedAuthor | Park, Jung Tak | - |
dc.contributor.affiliatedAuthor | An, Seong Yeong | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Yun, Hae Ryong | - |
dc.contributor.affiliatedAuthor | Lee, Mi Sol | - |
dc.contributor.affiliatedAuthor | Jhee, Jong Hyun | - |
dc.contributor.affiliatedAuthor | Cha, Min Uk | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.citation.volume | 111 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 389 | - |
dc.citation.endPage | 397 | - |
dc.identifier.bibliographicCitation | QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol.111(6) : 389-397, 2018 | - |
dc.identifier.rimsid | 58556 | - |
dc.type.rims | ART | - |
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