Cited 6 times in
Field Synopsis and Re-analysis of Systematic Meta-analyses of Genetic Association Studies in Multiple Sclerosis: a Bayesian Approach
DC Field | Value | Language |
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dc.contributor.author | 신재일 | - |
dc.contributor.author | 이금화 | - |
dc.date.accessioned | 2018-09-28T08:57:15Z | - |
dc.date.available | 2018-09-28T08:57:15Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0893-7648 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163265 | - |
dc.description.abstract | To provide an up-to-date summary of multiple sclerosis-susceptible gene variants and assess the noteworthiness in hopes of finding true associations, we investigated the results of 44 meta-analyses on gene variants and multiple sclerosis published through December 2016. Out of 70 statistically significant genotype associations, roughly a fifth (21%) of the comparisons showed noteworthy false-positive rate probability (FPRP) at a statistical power to detect an OR of 1.5 and at a prior probability of 10-6 assumed for a random single nucleotide polymorphism. These associations (IRF8/rs17445836, STAT3/rs744166, HLA/rs4959093, HLA/rs2647046, HLA/rs7382297, HLA/rs17421624, HLA/rs2517646, HLA/rs9261491, HLA/rs2857439, HLA/rs16896944, HLA/rs3132671, HLA/rs2857435, HLA/rs9261471, HLA/rs2523393, HLA-DRB1/rs3135388, RGS1/rs2760524, PTGER4/rs9292777) also showed a noteworthy Bayesian false discovery probability (BFDP) and one additional association (CD24 rs8734/rs52812045) was also noteworthy via BFDP computation. Herein, we have identified several noteworthy biomarkers of multiple sclerosis susceptibility. We hope these data are used to study multiple sclerosis genetics and inform future screening programs. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Humana Press | - |
dc.relation.isPartOf | MOLECULAR NEUROBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Field Synopsis and Re-analysis of Systematic Meta-analyses of Genetic Association Studies in Multiple Sclerosis: a Bayesian Approach | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pediatrics | - |
dc.contributor.googleauthor | Jae Hyon Park | - |
dc.contributor.googleauthor | Joo Hi Kim | - |
dc.contributor.googleauthor | Kye Eun Jo | - |
dc.contributor.googleauthor | Se Whan Na | - |
dc.contributor.googleauthor | Michael Eisenhut | - |
dc.contributor.googleauthor | Andreas Kronbichler | - |
dc.contributor.googleauthor | Keum Hwa Lee | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.identifier.doi | 10.1007/s12035-017-0773-2 | - |
dc.contributor.localId | A02142 | - |
dc.contributor.localId | A04622 | - |
dc.relation.journalcode | J03461 | - |
dc.identifier.eissn | 1559-1182 | - |
dc.identifier.pmid | 29027112 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12035-017-0773-2 | - |
dc.subject.keyword | BFDP | - |
dc.subject.keyword | FPRP | - |
dc.subject.keyword | Gene variant | - |
dc.subject.keyword | Meta-analysis | - |
dc.subject.keyword | Multiple sclerosis | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.alternativeName | Lee, Geum Hwa | - |
dc.contributor.affiliatedAuthor | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | Lee, Geum Hwa | - |
dc.citation.volume | 55 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 5672 | - |
dc.citation.endPage | 5688 | - |
dc.identifier.bibliographicCitation | MOLECULAR NEUROBIOLOGY, Vol.55(7) : 5672-5688, 2018 | - |
dc.identifier.rimsid | 58530 | - |
dc.type.rims | ART | - |
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