Cited 27 times in
Sensitization to Various Minor House Dust Mite Allergens is greater in patients with Atopic Dermatitis Than in Those with Respiratory Allergic Disease
DC Field | Value | Language |
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dc.contributor.author | 박경희 | - |
dc.contributor.author | 박중원 | - |
dc.contributor.author | 박창욱 | - |
dc.contributor.author | 신정우 | - |
dc.contributor.author | 이광훈 | - |
dc.contributor.author | 이상철 | - |
dc.contributor.author | 이재현 | - |
dc.contributor.author | 정경용 | - |
dc.date.accessioned | 2018-09-28T08:52:17Z | - |
dc.date.available | 2018-09-28T08:52:17Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0954-7894 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163177 | - |
dc.description.abstract | BACKGROUND: Various allergenic proteins are produced by house dust mites (HDM). However, the allergenicity and clinical implications of these allergens are unknown. OBJECTIVE: The purpose of this study was to identify allergens in Dermatophagoides farinae and elucidate the sensitization profiles to these in Korean patients suffering from respiratory (allergic rhinitis and/or asthma) and atopic dermatitis symptoms. METHODS: IgE reactivities in sera from 160 HDM allergy patients were analysed by one- and two-dimensional gel electrophoresis and immunoblotting. IgE-reactive components were identified by liquid chromatography-coupled electrospray ionization-tandem mass spectrometry. Nine recombinant mite allergens (Der f 1, Der f 2, Der f 10, Der f 11, Der f 13, Der f 14, Der f 30, Der f 32 and Der f Alt a 10) were produced, and the IgE reactivity in sera to each was determined by ELISAs. RESULTS: Der f 1 and Der f 2 were recognized by IgE in serum samples from 88.1% and 78.1% of all patients, respectively. Patients with respiratory allergies were mainly sensitized to these major allergens, whereas patients with atopic dermatitis symptoms showed polysensitization to major and minor allergen components (including Der f 11, Der f 13, Der f 14, Der f 32 and Der f Alt a 10). CONCLUSIONS: Patients with respiratory allergic disease sensitize to major allergen components of HDM. Those with atopic dermatitis were sensitized to a broader range of minor allergen components of HDM (Der f 11, Der f 13, Der f 14, Der f 32 and Der f Alt a 10). | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Scientific Publications | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL ALLERGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Sensitization to Various Minor House Dust Mite Allergens is greater in patients with Atopic Dermatitis Than in Those with Respiratory Allergic Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | K. H. Park | - |
dc.contributor.googleauthor | J. Lee | - |
dc.contributor.googleauthor | J.‐Y. Lee | - |
dc.contributor.googleauthor | S. C. Lee | - |
dc.contributor.googleauthor | D. W. Sim | - |
dc.contributor.googleauthor | J. U. Shin | - |
dc.contributor.googleauthor | C. O. Park | - |
dc.contributor.googleauthor | J.‐H. Lee | - |
dc.contributor.googleauthor | K. H. Lee | - |
dc.contributor.googleauthor | K. Y. Jeong | - |
dc.contributor.googleauthor | J.‐W. Park | - |
dc.identifier.doi | 10.1111/cea.13164 | - |
dc.contributor.localId | A01427 | - |
dc.contributor.localId | A01681 | - |
dc.contributor.localId | A01716 | - |
dc.contributor.localId | A02149 | - |
dc.contributor.localId | A02674 | - |
dc.contributor.localId | A02831 | - |
dc.contributor.localId | A03086 | - |
dc.contributor.localId | A03572 | - |
dc.relation.journalcode | J00548 | - |
dc.identifier.eissn | 1365-2222 | - |
dc.identifier.pmid | 29700921 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13164 | - |
dc.subject.keyword | allergic rhinitis | - |
dc.subject.keyword | asthma | - |
dc.subject.keyword | atopic dermatitis | - |
dc.subject.keyword | house dust mite | - |
dc.subject.keyword | recombinant allergen | - |
dc.contributor.alternativeName | Park, Kyung Hee | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.alternativeName | Park, Chang Ook | - |
dc.contributor.alternativeName | Shin, Jung U | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.alternativeName | Lee, Sang Chul | - |
dc.contributor.alternativeName | Lee, Jae Hyun | - |
dc.contributor.alternativeName | Jeong, Kyoung Yong | - |
dc.contributor.affiliatedAuthor | Park, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Park, Chang Ook | - |
dc.contributor.affiliatedAuthor | Shin, Jung U | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Sang Chul | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Jeong, Kyoung Yong | - |
dc.citation.volume | 48 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1050 | - |
dc.citation.endPage | 1058 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL ALLERGY, Vol.48(8) : 1050-1058, 2018 | - |
dc.identifier.rimsid | 58445 | - |
dc.type.rims | ART | - |
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