Cited 32 times in
Correlation between gamma-glutamyl transpeptidase activity and outcomes after Kasai portoenterostomy for biliary atresia
DC Field | Value | Language |
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dc.contributor.author | 인경 | - |
dc.contributor.author | 장은영 | - |
dc.contributor.author | 한석주 | - |
dc.contributor.author | 호인걸 | - |
dc.date.accessioned | 2018-08-28T17:02:46Z | - |
dc.date.available | 2018-08-28T17:02:46Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0022-3468 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162197 | - |
dc.description.abstract | BACKGROUND/PURPOSE: The role of serum gamma-glutamyl transpeptidase (GGT) levels in predicting clinical outcomes after Kasai portoenterostomy (KPE) is unknown. This study analyzed whether postoperative GGT along with the aspartate aminotransferase-to-platelet ratio index (APRi) predicted prognosis of biliary atresia (BA). METHODS: Data were retrospectively reviewed for 169 BA patients categorized into jaundice-free (JF) (total bilirubin <2.0 mg/dL </=6 months post-KPE) and persistent jaundice (PJ) groups (total bilirubin >/=2.0 mg/dL </=6 months post-KPE). Serum biochemical markers, including GGT levels, were measured monthly after KPE, and mean GGT levels and APRi were compared between groups. Factors predicting native liver survival (NLS) were determined using a Cox regression analysis. RESULTS: GGT concentrations >550 IU/L at month 5 (hazard ratio: 1.74, P < 0.05), an APRi >0.605 at month 4 (hazard ratio: 3.78, P = 0.001), and being jaundice-free at 6 months (hazard ratio: 5.49, P < 0.001) were independent risk factors for decreased NLS. CONCLUSIONS: Serum GGT concentrations >550 IU/L at month 5 and an APRi >0.605 at month 4 post-KPE were associated with significantly lower NLS rates. Among JF patients, those with GGT concentrations >550 IU/L at month 5 and APRi >0.605 at month 4 showed poorer outcomes. TYPE OF STUDY: Retrospective comparative study LEVEL OF EVIDENCE: Level III. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Saunders | - |
dc.relation.isPartOf | JOURNAL OF PEDIATRIC SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Correlation between gamma-glutamyl transpeptidase activity and outcomes after Kasai portoenterostomy for biliary atresia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | Kyong Ihn | - |
dc.contributor.googleauthor | In Geol Ho | - |
dc.contributor.googleauthor | Eun Young Chang | - |
dc.contributor.googleauthor | Seok Joo Han | - |
dc.identifier.doi | 10.1016/j.jpedsurg.2017.10.001 | - |
dc.contributor.localId | A05505 | - |
dc.contributor.localId | A03459 | - |
dc.contributor.localId | A04288 | - |
dc.contributor.localId | A04706 | - |
dc.relation.journalcode | J01689 | - |
dc.identifier.eissn | 1531-5037 | - |
dc.identifier.pmid | 29056230 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0022346817306164 | - |
dc.subject.keyword | Aspartate aminotransferase-to-platelet ratio index | - |
dc.subject.keyword | Biliary atresia | - |
dc.subject.keyword | Gamma-glutamyl transpeptidase | - |
dc.subject.keyword | Kasai portoenterostomy | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Ihn, Kyong | - |
dc.contributor.alternativeName | Chang, Eun Young | - |
dc.contributor.alternativeName | Han, Seok Joo | - |
dc.contributor.alternativeName | Hu, Jen Chien | - |
dc.contributor.affiliatedAuthor | Ihn, Kyong | - |
dc.contributor.affiliatedAuthor | Chang, Eun Young | - |
dc.contributor.affiliatedAuthor | Han, Seok Joo | - |
dc.contributor.affiliatedAuthor | Hu, Jen Chien | - |
dc.citation.volume | 53 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 461 | - |
dc.citation.endPage | 467 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PEDIATRIC SURGERY, Vol.53(3) : 461-467, 2018 | - |
dc.identifier.rimsid | 59783 | - |
dc.type.rims | ART | - |
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