Cited 13 times in
Isoform specific gene expression analysis of KRAS in the prognosis of lung adenocarcinoma patients
DC Field | Value | Language |
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dc.contributor.author | 김상우 | - |
dc.contributor.author | 양인석 | - |
dc.date.accessioned | 2018-08-28T16:57:26Z | - |
dc.date.available | 2018-08-28T16:57:26Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162109 | - |
dc.description.abstract | BACKGROUND: Aberrant mutations in KRAS play a critical role in tumor initiation and progression, and are a negative prognosis factor in lung adenocarcinoma (LUAD). RESULTS: Using genomic analysis for K-Ras isoforms (K-Ras4A and K-Ras4B) and large-scale multi-omics data, we inspected the overall survival (OS) and disease-free survival (DFS) of LUAD patients based on the abundance of transcript variants by analyzing RNA expression and somatic mutation data from The Cancer Genome Atlas (n = 516). The expression of the minor transcript K-Ras4A and its proportion were positively correlated with the presence of KRAS mutations in LUAD. We found that both K-Ras4A abundance measures (expression and proportion) have a strong association with poor OS (p = 0.0149 and p = 3.18E-3, respectively) and DFS (p = 3.03E-4 and p = 0.0237, respectively), but only in patients harboring KRAS mutations. A Cox regression analysis showed significant results in groups with low expression (hazard ratio (HR) = 2.533, 95% confidence interval (CI) = 1.380-4.651, p = 2.72E-3) and low proportion (HR = 2.549, 95% CI = 1.387-4.684, p = 2.58E-3) of K-Ras4A. CONCLUSIONS: Based on the above results, we report the possible use of abundance measures for K-Ras4A for predicting the survival of LUAD patients with KRAS mutations. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC BIOINFORMATICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Isoform specific gene expression analysis of KRAS in the prognosis of lung adenocarcinoma patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | In Seok Yang | - |
dc.contributor.googleauthor | Sangwoo Kim | - |
dc.identifier.doi | 10.1186/s12859-018-2011-y | - |
dc.contributor.localId | A00524 | - |
dc.relation.journalcode | J00350 | - |
dc.identifier.eissn | 1471-2105 | - |
dc.identifier.pmid | 29504894 | - |
dc.subject.keyword | Isoform specific expression | - |
dc.subject.keyword | K-Ras4A | - |
dc.subject.keyword | KRAS mutation | - |
dc.subject.keyword | Lung adenocarcinoma | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Kim, Sang Woo | - |
dc.contributor.affiliatedAuthor | Kim, Sang Woo | - |
dc.citation.volume | 19 | - |
dc.citation.number | Suppl 1 | - |
dc.citation.startPage | 40 | - |
dc.identifier.bibliographicCitation | BMC BIOINFORMATICS, Vol.19(Suppl 1) : 40, 2018 | - |
dc.identifier.rimsid | 59698 | - |
dc.type.rims | ART | - |
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