Cited 42 times in
A Randomized Multicenter Study Comparing 0.1%, 0.15%, and 0.3% Sodium Hyaluronate with 0.05% Cyclosporine in the Treatment of Dry Eye
DC Field | Value | Language |
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dc.contributor.author | 이형근 | - |
dc.date.accessioned | 2018-07-20T08:08:07Z | - |
dc.date.available | 2018-07-20T08:08:07Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1080-7683 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160864 | - |
dc.description.abstract | PURPOSE: To investigate the efficacy of 0.1%, 0.15%, and 0.3% sodium hyaluronate (SH) artificial tears compared with 0.05% cyclosporine (CS) ophthalmic solution for the treatment of dry eye. METHODS: One hundred seventy-six patients were recruited and randomized to receive of 0.1%, 0.15%, and 0.3% SH and 0.05% CS. There was a primary end point which is the changes in the fluorescein corneal staining (FCS) score to determine noninferiority of 0.1%, 0.15%, and 0.3% SH. Secondary objective end points were lissamine green conjunctival staining (LGCS) scores, Schirmer test, and tear film break-up time (TBUT). Secondary subjective end point was ocular surface disease index (OSDI) score. These were evaluated before treatment and 6 and 12 weeks after start of treatment. RESULTS: In the primary analysis, the mean change from baseline in FCS scores verified noninferiority of 0.1% and 0.15% SH to 0.05% CS and also indicated significant improvement of all groups (P < 0.05). Values for TBUT, LGCS scores, and OSDI scores showed significant improvements in all groups (P < 0.05), although no significant intergroup difference was shown. However, Schirmer test scores in the 0.15% SH group showed a significant tendency for better improvement at week 12 compared with the other groups (P < 0.05). No serious adverse events were observed. CONCLUSIONS: Administration of 0.1%, 0.15%, and 0.3% SH was effective in improving both the objective signs and subjective symptoms of dry eye. Those findings, in addition to the well-tolerated profile of 0.1%, 0.15%, and 0.3% SH, show that it is effective therapeutic method for dry eye. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Association For Ocular Pharmacology And Therapeutics | - |
dc.relation.isPartOf | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cyclosporine/administration & dosage | - |
dc.subject.MESH | Cyclosporine/adverse effects | - |
dc.subject.MESH | Cyclosporine/therapeutic use* | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Dry Eye Syndromes/drug therapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyaluronic Acid/administration & dosage | - |
dc.subject.MESH | Hyaluronic Acid/adverse effects | - |
dc.subject.MESH | Hyaluronic Acid/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Ophthalmic Solutions/administration & dosage | - |
dc.subject.MESH | Ophthalmic Solutions/adverse effects | - |
dc.subject.MESH | Ophthalmic Solutions/therapeutic use* | - |
dc.title | A Randomized Multicenter Study Comparing 0.1%, 0.15%, and 0.3% Sodium Hyaluronate with 0.05% Cyclosporine in the Treatment of Dry Eye | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Ophthalmology | - |
dc.contributor.googleauthor | Yuli Park | - |
dc.contributor.googleauthor | Jong Suk Song | - |
dc.contributor.googleauthor | Chul Young Choi | - |
dc.contributor.googleauthor | Kyung Chul Yoon | - |
dc.contributor.googleauthor | Hyung Keun Lee | - |
dc.contributor.googleauthor | Hyun Seung Kim | - |
dc.identifier.doi | 10.1089/jop.2016.0086 | - |
dc.contributor.localId | A03303 | - |
dc.relation.journalcode | J01654 | - |
dc.identifier.eissn | 1557-7732 | - |
dc.identifier.pmid | 27929721 | - |
dc.subject.keyword | 0.05% cyclosporine | - |
dc.subject.keyword | 0.1% sodium hyaluronate | - |
dc.subject.keyword | 0.15% sodium hyaluronate | - |
dc.subject.keyword | 0.3% sodium hyaluronate | - |
dc.subject.keyword | dry eye syndrome | - |
dc.contributor.alternativeName | Lee, Hyung Keun | - |
dc.contributor.affiliatedAuthor | Lee, Hyung Keun | - |
dc.citation.volume | 33 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 66 | - |
dc.citation.endPage | 72 | - |
dc.identifier.bibliographicCitation | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, Vol.33(2) : 66-72, 2017 | - |
dc.identifier.rimsid | 60748 | - |
dc.type.rims | ART | - |
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