Cited 71 times in
The Effects of Perioperative Anesthesia and Analgesia on Immune Function in Patients Undergoing Breast Cancer Resection: A Prospective Randomized Study
DC Field | Value | Language |
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dc.contributor.author | 구본녀 | - |
dc.contributor.author | 김승일 | - |
dc.contributor.author | 박세호 | - |
dc.contributor.author | 박형석 | - |
dc.contributor.author | 조진선 | - |
dc.date.accessioned | 2018-07-20T07:51:57Z | - |
dc.date.available | 2018-07-20T07:51:57Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160611 | - |
dc.description.abstract | Introduction: Perioperative anesthesia and analgesia exacerbate immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. We compared the effects of two different anesthesia and analgesia methods on the NK cell cytotoxicity (NKCC) in patients undergoing breast cancer surgery. Methods: Fifty patients undergoing breast cancer resection were randomly assigned to receive propofol-remifentanil anesthesia with postoperative ketorolac analgesia (Propofol-ketorolac groups) or sevoflurane-remifentanil anesthesia with postoperative fentanyl analgesia (Sevoflurane-fentanyl group). The primary outcome was NKCC, which was measured before and 24 h after surgery. Post-surgical pain scores and inflammatory responses measured by white blood cell, neutrophil, and lymphocyte counts were assessed. Cancer recurrence or metastasis was evaluated with ultrasound and whole body bone scan every 6 months for 2 years after surgery. Results: The baseline NKCC (%) was comparable between the two groups (P = 0.082). Compared with the baseline value, NKCC (%) increased in the Propofol-ketorolac group [15.2 (3.2) to 20.1 (3.5), P = 0.048], whereas it decreased in the Sevoflurane-fentanyl group [19.5 (2.8) to 16.4 (1.9), P = 0.032]. The change of NKCC over time was significantly different between the groups (P = 0.048). Pain scores during 48 h after surgery and post-surgical inflammatory responses were comparable between the groups. One patient in the Sevoflurane-fentanyl group had recurrence in the contralateral breast and no metastasis was found in either group. Conclusions: Propofol anesthesia with postoperative ketorolac analgesia demonstrated a favorable impact on immune function by preserving NKCC compared with sevoflurane anesthesia and postoperative fentanyl analgesia in patients undergoing breast cancer surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Ivyspring International Publisher | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Analgesia/adverse effects* | - |
dc.subject.MESH | Analgesia/methods | - |
dc.subject.MESH | Analgesics, Opioid/adverse effects | - |
dc.subject.MESH | Anesthesia/adverse effects* | - |
dc.subject.MESH | Anesthesia/methods | - |
dc.subject.MESH | Anesthetics, Inhalation/adverse effects | - |
dc.subject.MESH | Breast Neoplasms/immunology* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Breast Neoplasms/surgery | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fentanyl/adverse effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunity, Cellular/drug effects* | - |
dc.subject.MESH | Immunocompromised Host/drug effects | - |
dc.subject.MESH | Immunocompromised Host/immunology | - |
dc.subject.MESH | Killer Cells, Natural/drug effects* | - |
dc.subject.MESH | Killer Cells, Natural/immunology | - |
dc.subject.MESH | Methyl Ethers/adverse effects | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pain Management/adverse effects* | - |
dc.subject.MESH | Pain Management/methods | - |
dc.subject.MESH | Pain Measurement | - |
dc.subject.MESH | Perioperative Care/adverse effects | - |
dc.subject.MESH | Piperidines/adverse effects | - |
dc.subject.MESH | Propofol/adverse effects | - |
dc.subject.MESH | Prospective Studies | - |
dc.title | The Effects of Perioperative Anesthesia and Analgesia on Immune Function in Patients Undergoing Breast Cancer Resection: A Prospective Randomized Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Jin Sun Cho | - |
dc.contributor.googleauthor | Mi-Hyang Lee | - |
dc.contributor.googleauthor | Seung Il Kim | - |
dc.contributor.googleauthor | Seho Park | - |
dc.contributor.googleauthor | Hyung Seok Park | - |
dc.contributor.googleauthor | Ein Oh | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.contributor.googleauthor | Bon-Nyeo Koo | - |
dc.identifier.doi | 10.7150/ijms.20064 | - |
dc.contributor.localId | A00193 | - |
dc.contributor.localId | A00658 | - |
dc.contributor.localId | A01524 | - |
dc.contributor.localId | A01753 | - |
dc.contributor.localId | A03914 | - |
dc.relation.journalcode | J02917 | - |
dc.identifier.eissn | 1449-1907 | - |
dc.identifier.pmid | 28924368 | - |
dc.subject.keyword | analgesia | - |
dc.subject.keyword | anesthesia | - |
dc.subject.keyword | breast cancer | - |
dc.subject.keyword | immunity | - |
dc.subject.keyword | natural killer cell | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.alternativeName | Kim, Seung Il | - |
dc.contributor.alternativeName | Park, Se Ho | - |
dc.contributor.alternativeName | Park, Hyung Seok | - |
dc.contributor.alternativeName | Cho, Jin Sun | - |
dc.contributor.affiliatedAuthor | Ku, Bon Nyo | - |
dc.contributor.affiliatedAuthor | Kim, Seung Il | - |
dc.contributor.affiliatedAuthor | Park, Se Ho | - |
dc.contributor.affiliatedAuthor | Park, Hyung Seok | - |
dc.contributor.affiliatedAuthor | Cho, Jin Sun | - |
dc.citation.volume | 14 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 970 | - |
dc.citation.endPage | 976 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, Vol.14(10) : 970-976, 2017 | - |
dc.identifier.rimsid | 40021 | - |
dc.type.rims | ART | - |
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