한국형 양극성 장애 약물치료 알고리듬 2010 : 급속 순환

Abstract

Objectives : Bipolar disorder is an illness with significant morbidity and mortality that contributes to disturb social function. Our objective for this study is to revise Korean Medication Algorithm Project for Bipolar Disorder 2006 for rapid cycling.

Methods : The questionnaires to survey the expert opinion of medication for rapid cycling were completed by the review committee consisting of 70 Korean expert psychiatrists. We classified the experts’ opinion to 3 categories based on the lowest category in which the confidence interval fall (6.5≤ for first-line and 3.5≤ for second-line treatment).

Results : The first-line treatment is the combination of a mood stabilizer and an atypical antipsychotic. Combination of two mood stabilizers was preferred as next strategy. The first-line medications in all cases are valproic acid, lithium, quetiapine, and olanzapine. For the treatment of depressive phase, lamotrigine is the first-line medication.

Conclusion : Compared to the surveys in 2006, the preference for lamotrigine and atypical antipsychotics has increased while that of carbamazepine and antidepressant has decreased. (J of Kor Soc for Dep and Bip Disorders 2011;9:103-108)