Cited 117 times in
Drug-loaded gold/iron/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis
DC Field | Value | Language |
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dc.contributor.author | 문진희 | - |
dc.contributor.author | 박용범 | - |
dc.date.accessioned | 2018-03-26T16:40:34Z | - |
dc.date.available | 2018-03-26T16:40:34Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156699 | - |
dc.description.abstract | We have developed methotrexate (MTX)-loaded poly(lactic-co-glycolic acid, PLGA) gold (Au)/iron (Fe)/gold (Au) half-shell nanoparticles conjugated with arginine-glycine-aspartic acid (RGD), which can be applied for magnetic targeted chemo-photothermal treatment, and in vivo multimodal imaging of rheumatoid arthritis (RA). Upon near-infrared (NIR) irradiation, local heat is generated at the inflammation region due to the NIR resonance of Au half-shells and MTX release from PLGA nanoparticles is accelerated. The Fe half-shell layer embedded between the Au half-shell layers enables in vivo T2-magnetic resonance (MR) imaging in addition to NIR absorbance imaging. Furthermore, the delivery of the nanoparticles to the inflammation region in collagen-induced arthritic (CIA) mice, and their retention can be enhanced under external magnetic field. When combined with consecutive NIR irradiation and external magnetic field application, these nanoparticles provide enhanced therapeutic effects with an MTX dosages of only 0.05% dosage compared to free MTX therapy for the treatment of RA. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antirheumatic Agents/administration & dosage | - |
dc.subject.MESH | Arthritis, Rheumatoid/drug therapy* | - |
dc.subject.MESH | Arthritis, Rheumatoid/pathology* | - |
dc.subject.MESH | Combined Modality Therapy/methods | - |
dc.subject.MESH | Contrast Media/chemical synthesis | - |
dc.subject.MESH | Delayed-Action Preparations/administration & dosage | - |
dc.subject.MESH | Delayed-Action Preparations/chemical synthesis | - |
dc.subject.MESH | Diffusion | - |
dc.subject.MESH | Gold/chemistry | - |
dc.subject.MESH | Gold/therapeutic use | - |
dc.subject.MESH | Iron/chemistry | - |
dc.subject.MESH | Iron/therapeutic use | - |
dc.subject.MESH | Light | - |
dc.subject.MESH | Magnetic Fields | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metal Nanoparticles/chemistry* | - |
dc.subject.MESH | Metal Nanoparticles/ultrastructure | - |
dc.subject.MESH | Methotrexate/administration & dosage* | - |
dc.subject.MESH | Methotrexate/chemistry | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred DBA | - |
dc.subject.MESH | Molecular Imaging/methods | - |
dc.subject.MESH | Nanocapsules/chemistry | - |
dc.subject.MESH | Nanocapsules/radiation effects | - |
dc.subject.MESH | Nanocapsules/therapeutic use* | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Photochemotherapy/methods* | - |
dc.subject.MESH | Photosensitizing Agents/administration & dosage | - |
dc.subject.MESH | Photosensitizing Agents/chemistry | - |
dc.subject.MESH | Surface Plasmon Resonance/methods | - |
dc.subject.MESH | Theranostic Nanomedicine/methods | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Drug-loaded gold/iron/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Yonsei Biomedical Research Center | - |
dc.contributor.googleauthor | Hyung Joon Kim | - |
dc.contributor.googleauthor | Sun-Mi Lee | - |
dc.contributor.googleauthor | Kyu-Hyung Park | - |
dc.contributor.googleauthor | Chin Hee Mun | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Kyung-Hwa Yoo | - |
dc.identifier.doi | 10.1016/j.biomaterials.2015.05.018 | - |
dc.contributor.localId | A01388 | - |
dc.contributor.localId | A01579 | - |
dc.relation.journalcode | J00312 | - |
dc.identifier.eissn | 1878-5905 | - |
dc.identifier.pmid | 26001074 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0142961215004688 | - |
dc.subject.keyword | Drug-loaded Au plasmonic nanoparticles | - |
dc.subject.keyword | Drug-loaded Au/Fe/Au plasmonic nanoparticles | - |
dc.subject.keyword | chemo-photothermal treatment | - |
dc.subject.keyword | photothermally controlled drug delivery, multidrug resistance in cancer, rheumatoid arthritis | - |
dc.contributor.alternativeName | Mun, Chin Hee | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Mun, Chin Hee | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.citation.volume | 61 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 102 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, Vol.61 : 95-102, 2015 | - |
dc.identifier.rimsid | 39830 | - |
dc.type.rims | ART | - |
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