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Differential Site-Based Expression of Pentose Phosphate Pathway-Related Proteins among Breast Cancer Metastases
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 정우희 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2017-11-02T08:12:49Z | - |
dc.date.available | 2017-11-02T08:12:49Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0278-0240 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154206 | - |
dc.description.abstract | Purpose : We aimed to investigate the expression of pentose phosphate pathway- (PPP-) related proteins in metastatic breast cancer and its relationship with clinicopathologic factors. Methods : Tissue samples from 126 metastatic breast cancers were included in a tissue microarray. Expression of PPP-related proteins [glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconolactonase (6PGL), 6-phosphogluconate dehydrogenase (6PGDH), and nuclear factor erythroid 2-related factor (NRF2)] was determined by immunohistochemistry. Results. G6PDH (p = 0.011) and cytoplasmic NRF2 (p = 0.001) showed the highest expression in brain metastases. Human epidermal growth factor receptor (HER-2) positivity was associated with G6PDH (p < 0.001) and cytoplasmic NRF2 (p = 0.015) positivity. A high Ki-67 labeling index (LI) was correlated with nuclear NRF2 positivity (p = 0.037), and HER-2-positive luminal B type was associated with G6PDH positivity (p = 0.001). On multivariate Cox analysis, independent risk factors of short overall survival were 6PGL positivity in bone metastasis (HR 4.180, 95% CI 1.160-15.06, p = 0.029) and low Ki-67 LI in lung metastasis (HR 11.853, 95% CI 1.841-76.30, p = 0.009). Conclusion : Differential expression of PPP-related proteins correlated with different prognoses and metastatic sites, with the highest expression in brain metastases, and could be a potential therapeutic target. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Hindawi Pub. Corp. | - |
dc.relation.isPartOf | DISEASE MARKERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Bone Neoplasms/secondary | - |
dc.subject.MESH | Bone and Bones/pathology | - |
dc.subject.MESH | Brain Neoplasms/secondary | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Carboxylic Ester Hydrolases/metabolism | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/metabolism* | - |
dc.subject.MESH | Cytoplasm/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ki-67 Antigen/metabolism | - |
dc.subject.MESH | Liver Neoplasms/secondary | - |
dc.subject.MESH | Lung Neoplasms/secondary | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | NF-E2-Related Factor 2/metabolism* | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Pentose Phosphate Pathway* | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Phosphogluconate Dehydrogenase/metabolism | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Receptor, ErbB-2/metabolism | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Tissue Array Analysis | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Differential Site-Based Expression of Pentose Phosphate Pathway-Related Proteins among Breast Cancer Metastases | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Woo Hee Jung | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1155/2017/7062517 | - |
dc.contributor.localId | A03671 | - |
dc.contributor.localId | A04001 | - |
dc.contributor.localId | A00198 | - |
dc.relation.journalcode | J00743 | - |
dc.identifier.eissn | 1875-8630 | - |
dc.identifier.pmid | 28260828 | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.alternativeName | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.title | Disease Markers | - |
dc.citation.volume | 2017 | - |
dc.citation.startPage | 7062517 | - |
dc.identifier.bibliographicCitation | DISEASE MARKERS, Vol.2017 : 7062517, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42175 | - |
dc.type.rims | ART | - |
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