Cited 28 times in
Use of benzodiazepine and risk of cancer: A meta-analysis of observational studies
DC Field | Value | Language |
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dc.contributor.author | 박병진 | - |
dc.date.accessioned | 2017-11-02T08:06:10Z | - |
dc.date.available | 2017-11-02T08:06:10Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154078 | - |
dc.description.abstract | Several observational epidemiological studies have reported inconsistent results on the association between the use of benzodiazepine and the risk of cancer. We investigated the association by using a meta-analysis. We searched PubMed, EMBASE, and the bibliographies of relevant articles to locate additional publications in January 2016. Three evaluators independently reviewed and selected eligible studies based on predetermined selection criteria. Of 796 articles meeting our initial criteria, a total of 22 observational epidemiological studies with 18 case-control studies and 4 cohort studies were included in the final analysis. Benzodiazepine use was significantly associated with an increased risk of cancer (odds ratio [OR] or relative risk [RR] 1.19; 95% confidence interval 1.16-1.21) in a random-effects meta-analysis of all studies. Subgroup meta-analyses by various factors such as study design, type of case-control study, study region, and methodological quality of study showed consistent findings. Also, a significant dose-response relationship was observed between the use of benzodiazepine and the risk of cancer (p for trend <0.01). The current meta-analysis of observational epidemiological studies suggests that benzodiazepine use is associated with an increased risk of cancer. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Benzodiazepines/adverse effects* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neoplasms/chemically induced* | - |
dc.subject.MESH | Observational Studies as Topic | - |
dc.subject.MESH | Research Design | - |
dc.subject.MESH | Risk | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Young Adult | - |
dc.title | Use of benzodiazepine and risk of cancer: A meta-analysis of observational studies | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Family Medicine | - |
dc.contributor.googleauthor | Hong-Bae Kim | - |
dc.contributor.googleauthor | Seung-Kwon Myung | - |
dc.contributor.googleauthor | Yon Chul Park | - |
dc.contributor.googleauthor | Byoungjin Park | - |
dc.identifier.doi | 10.1002/ijc.30443 | - |
dc.contributor.localId | A01477 | - |
dc.relation.journalcode | J01092 | - |
dc.identifier.eissn | 1097-0215 | - |
dc.identifier.pmid | 27667780 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/ijc.30443/abstract | - |
dc.subject.keyword | benzodiazepine | - |
dc.subject.keyword | cancer | - |
dc.subject.keyword | meta-analysis | - |
dc.subject.keyword | observational study | - |
dc.contributor.alternativeName | Park, Byoung Jin | - |
dc.contributor.affiliatedAuthor | Park, Byoung Jin | - |
dc.citation.title | International Journal of Cancer | - |
dc.citation.volume | 140 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 513 | - |
dc.citation.endPage | 525 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CANCER, Vol.140(3) : 513-525, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 41572 | - |
dc.type.rims | ART | - |
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