Cited 6 times in
Risk stratification for locally advanced hepatocellular carcinoma using pretreatment alpha-foetoprotein and 18F-fluoro-2-deoxyglucose positron emission tomography
DC Field | Value | Language |
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dc.contributor.author | 변화경 | - |
dc.contributor.author | 성진실 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | 황상현 | - |
dc.contributor.author | 이우중 | - |
dc.date.accessioned | 2017-11-01T08:58:34Z | - |
dc.date.available | 2017-11-01T08:58:34Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153863 | - |
dc.description.abstract | Background & Aims : We investigated the significance of 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET) parameters and alpha-foetoprotein (AFP) levels in patients with locally advanced hepatocellular carcinoma (LA-HCC). Methods : We retrospectively analysed data of 228 patients with LA-HCC who underwent pretreatment 18F-FDG PET between January 2003 and December 2013. All patients were treated using liver-directed therapy involving radiotherapy. The maximum standardized uptake values (SUVs) and tumour-to-extratumoural liver SUV ratios were calculated, and pretreatment AFP values were obtained. Results : Patients were divided into high and low maximum SUV (SUVmax) groups according to a SUV cut-off of 4.825 determined via receiver-operating characteristic analysis. High AFP level (>550 ng/mL) and high SUVmax were significant predictors of overall and progression-free survival. Better treatment responses and longer median progression-free and overall survival were observed in the low SUVmax group, compared to the high SUVmax group. Similar results were obtained for SUV ratio-based (cut-off value: 2.355) and AFP-based analyses (cut-off value: 550 ng/mL). Three risk groups were identified using the double biomarkers of SUVmax and AFP value as strong prognosticators predictive of survival outcomes. This risk stratification was identified as a prognosticator of survival outcomes, even after subgroup analyses. Furthermore, in high risk group, significantly high extrahepatic failure was shown while in low risk group, significantly low intrahepatic failure. Conclusions : Clinical significance of double biomarkers, SUV and AFP, could be translated into risk stratification for LA-HCC. It could be a valuable tool for survival outcome prediction. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Risk stratification for locally advanced hepatocellular carcinoma using pretreatment alpha-foetoprotein and 18F-fluoro-2-deoxyglucose positron emission tomography | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Woo Joong Rhee | - |
dc.contributor.googleauthor | Sang Hyun Hwang | - |
dc.contributor.googleauthor | Hwa Kyung Byun | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Jinsil Seong | - |
dc.identifier.doi | 10.1111/liv.13297 | - |
dc.contributor.localId | A01956 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A05136 | - |
dc.relation.journalcode | J02171 | - |
dc.identifier.eissn | 1478-3231 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/liv.13297/abstract | - |
dc.subject.keyword | alpha‐foetoprotein | - |
dc.subject.keyword | FDG‐PET | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | survival | - |
dc.subject.keyword | tumour aggressiveness | - |
dc.contributor.alternativeName | Byun, Hwa Kyung | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Byun, Hwa Kyung | - |
dc.citation.title | Liver International | - |
dc.citation.volume | 37 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 592 | - |
dc.citation.endPage | 599 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, Vol.37(4) : 592-599, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 43624 | - |
dc.type.rims | ART | - |
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