Cited 19 times in
Insulin-like growth factor-II mRNA binding protein-3 and podoplanin expression are associated with bone invasion and prognosis in oral squamous cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김진 | - |
dc.contributor.author | 장향란 | - |
dc.contributor.author | 차인호 | - |
dc.contributor.author | 안성용 | - |
dc.date.accessioned | 2017-10-26T08:03:36Z | - |
dc.date.available | 2017-10-26T08:03:36Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0003-9969 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152889 | - |
dc.description.abstract | OBJECTIVE: This study aimed to evaluate the prognostic implications of insulin-like growth factor-II mRNA binding protein-3 (IMP3) and podoplanin (PDPN) as therapeutic targets against oral squamous cell carcinoma (OSCC) with bone invasion. STUDY DESIGN: We elucidated the correlation of IMP3 and PDPN expression with bone invasion in 160 OSCC tissue specimens, and assessed a mouse calvarium xenograft model using an IMP3- and PDPN-depleted OSCC cell line. RESULTS: The retrospective analysis revealed that the expression of IMP3 and PDPN is significantly correlated with T stage, lymph node metastasis, and the overall survival of OSCC patients. In addition, the dual expression of IMP3 and PDPN but not the single expression of either IMP3 or PDPN was associated with bone invasion and the number of osteoclasts in patients with OSCC. In support of these findings, IMP3 or PDPN depletion inhibited the invasive capacity of OSCC cells in a three-dimensional culture system, tumorigenesis, and regional bone destruction in a xenograft mouse model. In addition, IMP3 or PDPN depletion inhibited the expression of interleukin (IL)-6 and IL-8 in OSCC cells, and decreased the expression of receptor activator of NF-κB ligand (RANKL) in xenograft tumor tissues of OSCC. CONCLUSIONS: These results suggest that IMP3 and PDPN may have strong influence on the pathogenesis of OSCC, especially in bone invasion, and may serve as novel therapeutic targets with prognostic implications for bone-invasive OSCC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.publisher | Pergamon Press | - |
dc.relation.isPartOf | ARCHIVES OF ORAL BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Insulin-like growth factor-II mRNA binding protein-3 and podoplanin expression are associated with bone invasion and prognosis in oral squamous cell carcinoma | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Oral Pathology | - |
dc.contributor.googleauthor | Young Sun Hwang | - |
dc.contributor.googleauthor | Sung Yong Ahn | - |
dc.contributor.googleauthor | Sook Moon | - |
dc.contributor.googleauthor | Zhenlong Zheng | - |
dc.contributor.googleauthor | In-Ho Cha | - |
dc.contributor.googleauthor | Jin Kim | - |
dc.contributor.googleauthor | Xianglan Zhang | - |
dc.identifier.doi | 10.1016/j.archoralbio.2016.05.008 | - |
dc.contributor.localId | A01009 | - |
dc.contributor.localId | A03489 | - |
dc.contributor.localId | A04002 | - |
dc.relation.journalcode | J00225 | - |
dc.identifier.eissn | 1879-1506 | - |
dc.identifier.pmid | 27232357 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0003996916301182?via%3Dihub | - |
dc.contributor.alternativeName | Kim, Jin | - |
dc.contributor.alternativeName | Zhang, Xiang Lan | - |
dc.contributor.alternativeName | Cha, In Ho | - |
dc.contributor.affiliatedAuthor | Kim, Jin | - |
dc.contributor.affiliatedAuthor | Zhang, Xiang Lan | - |
dc.contributor.affiliatedAuthor | Cha, In Ho | - |
dc.citation.volume | 69 | - |
dc.citation.startPage | 25 | - |
dc.citation.endPage | 32 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF ORAL BIOLOGY, Vol.69 : 25-32, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 40513 | - |
dc.type.rims | ART | - |
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