Cited 5 times in
Biomarker-specific conjugated nanopolyplexes for the active coloring of stem-like cancer cells
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.date.accessioned | 2017-10-26T07:40:27Z | - |
dc.date.available | 2017-10-26T07:40:27Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0957-4484 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152361 | - |
dc.description.abstract | Stem-like cancer cells possess intrinsic features and their CD44 regulate redox balance in cancer cells to survive under stress conditions. Thus, we have fabricated biomarker-specific conjugated polyplexes using CD44-targetable hyaluronic acid and redox-sensible polyaniline based on a nanoemulsion method. For the most sensitive recognition of the cellular redox at a single nanoparticle scale, a nano-scattering spectrum imaging analyzer system was introduced. The conjugated polyplexes showed a specific targeting ability toward CD44-expressing cancer cells as well as a dramatic change in its color, which depended on the redox potential in the light-scattered images. Therefore, these polyaniline-based conjugated polyplexes as well as analytical processes that include light-scattering imaging and measurements of scattering spectra, clearly establish a systematic method for the detection and monitoring of cancer microenvironments. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | IOP Pub. | - |
dc.relation.isPartOf | NANOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Biomarker-specific conjugated nanopolyplexes for the active coloring of stem-like cancer cells | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Yoochan Hong | - |
dc.contributor.googleauthor | Eugene Lee | - |
dc.contributor.googleauthor | Jihye Choi | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.identifier.doi | 10.1088/0957-4484/27/22/225101 | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A01916 | - |
dc.relation.journalcode | J02287 | - |
dc.identifier.eissn | 1361-6528 | - |
dc.identifier.pmid | 27098318 | - |
dc.identifier.url | http://iopscience.iop.org/article/10.1088/0957-4484/27/22/225101/meta | - |
dc.subject.keyword | polyaniline | - |
dc.subject.keyword | hyaluronic acid | - |
dc.subject.keyword | cancer | - |
dc.subject.keyword | colorimetric probes | - |
dc.subject.keyword | redox environment | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.citation.volume | 27 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 225101 | - |
dc.identifier.bibliographicCitation | NANOTECHNOLOGY, Vol.27(22) : 225101, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48095 | - |
dc.type.rims | ART | - |
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