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Efficacy evaluation of SurgiGuard® in partially hepatectomized pigs
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경식 | - |
dc.contributor.author | 김성현 | - |
dc.date.accessioned | 2017-10-26T07:33:45Z | - |
dc.date.available | 2017-10-26T07:33:45Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1738-6349 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152195 | - |
dc.description.abstract | Backgrounds/Aims: This study evaluated the hemostatic effects of a novel oxidized regenerated cellulose, SurgiGuard®, during liver surgery, using a reproducible and clinically relevant animal model. Methods: Fifteen mini-pigs underwent left partial hepatectomy. They were randomized to treatment of the resected surface with SurgiGuard® (Group C [test], n=5), Surgicel® (Group B [reference], n=5), or nothing (Group A [control], n=5). Blood loss was measured 5, 7 and 9 min after resection. Time to hemostasis was recorded. Mini-pigs were necropsied 4 or 6 weeks postoperatively to evaluate toxicity changes and material dissolution. Results: The median resected liver weight was 2.13 g (2.02-2.20) in control group, 2.04 g (2.01-2.13) in reference group, and 2.01 g (1.99-2.12) in test group (p=0.024). Median total blood loss was 57.18 g (52.02-59.54) in control group, 32.52 g (27.66-35.10) in reference group, and 35.52 g (25.70-38.71) in test group (p=0.008). Blood loss at 0-5 minutes and 7-9 minutes was significantly different between groups (p=0.009 and p=0.006, respectively). At necropsy, no hematomas, granulomas, or adhesions were noted in any group. Histopathological analysis revealed no changes suggesting toxicity related to SurgiGuard®. Conclusions: SurgiGuard® is as effective as Surgicel® in achieving hemostasis after porcine partial liver resection. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean Journal of Hepato-Biliary-Pancreatic Surgery | - |
dc.publisher | Korean Journal of Hepato-Biliary-Pancreatic Surgery | - |
dc.relation.isPartOf | Korean Journal of Hepato-Biliary-Pancreatic Surgery | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Efficacy evaluation of SurgiGuard® in partially hepatectomized pigs | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | Sung Hyun Kim | - |
dc.contributor.googleauthor | Hye Sung Yoon | - |
dc.contributor.googleauthor | Chang Hoon In | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.identifier.doi | 10.14701/kjhbps.2016.20.3.102 | - |
dc.contributor.localId | A04529 | - |
dc.contributor.localId | A00299 | - |
dc.relation.journalcode | J02035 | - |
dc.identifier.eissn | 2288-9213 | - |
dc.relation.journalsince | 1997~2015 | - |
dc.relation.journalafter | 2016~ Annals of Hepato-biliary-pancreatic Surgery | - |
dc.identifier.pmid | 27621746 | - |
dc.subject.keyword | Animal model | - |
dc.subject.keyword | Hemostatic | - |
dc.subject.keyword | Hepatectomy | - |
dc.subject.keyword | Histopathology | - |
dc.subject.keyword | Oxidized regenerated cellulose | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.alternativeName | Kim, Sung Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.citation.volume | 20 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 102 | - |
dc.citation.endPage | 109 | - |
dc.identifier.bibliographicCitation | Korean Journal of Hepato-Biliary-Pancreatic Surgery, Vol.20(3) : 102-109, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46973 | - |
dc.type.rims | ART | - |
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