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난소암 조직에서 HLA-G유전자 발현과 예후 인자와의 상관성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김상운 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김영태 | - |
dc.contributor.author | 김재욱 | - |
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 박용원 | - |
dc.date.accessioned | 2017-10-26T06:54:18Z | - |
dc.date.available | 2017-10-26T06:54:18Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1738-5628 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151472 | - |
dc.description.abstract | Objective: The objective of this study was to investigate the relationship between the expression of mRNA and protein of HLA-G and other clinicopathologic prognostic factors of ovarian cancer. Methods: 43 patients diagnosed with ovarian cancer from 1997 to 2005 and 5 patients with normal ovarian tissue (controls) were enrolled in this prospective study. The patient group all went through baseline studies with staging laparotomy and adjuvant chemotherapy. Quantitative real-time RT PCR and Western blot analysis were used in detecting the expression of mRNA and protein of HLA-G. Results: The mRNA expression of HLA-G (2-delta delta Ct value) in cancer group were 1.21 (0-9), and 0.01 (0-0.02) in control group, which was statistically significant (P=0.005). The expressed protein levels did not show any difference between the cancer and control groups. There also was a significant relationship between the serum CA 125 at the time of diagnosis and the HLA-G protein levels (P=0.02). But the relationship between other clinicopathologic prognostic factors and the HLA-G protein levels were not statistically significant. Conclusion: Our results showed that HLA-G mRNA expression level was much higher in ovarian cancer patient group than in those of control group. Therefore HLA-G maybe play an important role in carcinogenesis of ovarian cancer. Although the protein level of HLA-G had low significance with other prognostic factors, serum CA 125 showed a statistically significant relation with protein levels of HLA-G. Further studies based on the correlation between HLA-G and survival rate are needed to support HLA-G as a prognostic factor of ovarian cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한산부인과학회 | - |
dc.relation.isPartOf | Korean Journal of Obstetrics and Gynecology (대한산부인과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Ovarian cancer | - |
dc.subject.MESH | HLA-G gene | - |
dc.subject.MESH | CA-125 | - |
dc.subject.MESH | Prognostic factors | - |
dc.title | 난소암 조직에서 HLA-G유전자 발현과 예후 인자와의 상관성 | - |
dc.title.alternative | Correlation of HLA-G Gene Expression with Various Prognostic Factors in the Tissue of Ovarian Carcinoma | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | 홍원기 | - |
dc.contributor.googleauthor | 김영태 | - |
dc.contributor.googleauthor | 윤보성 | - |
dc.contributor.googleauthor | 김상운 | - |
dc.contributor.googleauthor | 김성훈 | - |
dc.contributor.googleauthor | 김재훈 | - |
dc.contributor.googleauthor | 김재욱 | - |
dc.contributor.googleauthor | 박용원 | - |
dc.identifier.doi | OAK-2005-06340 | - |
dc.contributor.localId | A00526 | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A00729 | - |
dc.contributor.localId | A00866 | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A01581 | - |
dc.relation.journalcode | J02076 | - |
dc.relation.journalsince | 1958~2004 | - |
dc.relation.journalafter | 2005~ Korean Journal of Obstetrics and Gynecology (대한산부인과학회지) | - |
dc.subject.keyword | Ovarian cancer | - |
dc.subject.keyword | HLA-G gene | - |
dc.subject.keyword | CA-125 | - |
dc.subject.keyword | Prognostic factors | - |
dc.contributor.alternativeName | Kim, Sang Wun | - |
dc.contributor.alternativeName | Kim, Sang Wun | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Young Tae | - |
dc.contributor.alternativeName | Kim, Jae Wook | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Park, Yong Won | - |
dc.contributor.affiliatedAuthor | 김상운 | - |
dc.citation.volume | 48 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2910 | - |
dc.citation.endPage | 2918 | - |
dc.identifier.bibliographicCitation | Korean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.48(12) : 2910-2918, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 44630 | - |
dc.type.rims | ART | - |
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