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Isolation of Saponins with the Inhibitory Effect on Nitric Oxide, Prostaglandin E2 and Tumor Necrosis Factor-α Production from Pleurospermum kamtschaticum
DC Field | Value | Language |
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dc.contributor.author | 박광균 | - |
dc.contributor.author | 정원윤 | - |
dc.date.accessioned | 2017-10-26T06:49:57Z | - |
dc.date.available | 2017-10-26T06:49:57Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151366 | - |
dc.description.abstract | As an attempt to search for bioactive natural products exerting antiinflammatory activity, we have isolated two saponins were isolated from the aerial portion of Pleurospermum kamtschaticum (Umbelliferae) by nitrite assay activity-directed chromatographic fractionation. They were identified as saikogenin F 3-O-{β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-β-D-fucopyranoside} (buddlejasaponin IV, 1) and 3β,16β,23,28-tetrahydroxy-11α-methoxyolean-12-ene 3-O-{β-D-glucopyranosyl(1→2)-[β-D-glucopyranosyl(1→3)]-β-D-fucopyranoside} (buddlejasaponin IVa, 2). Compound 1 significantly inhibited nitric oxide (NO) production, and it also significantly decreased prostaglandin E2 (PGE2) and tumor necrosis factor-α (TNF-α) release in the lipopolysaccharide (LPS)-activated macrophage Raw 264.7 cells whereas compound 2 was much less active. Saikogenin A (3) and –H (4) were obtained by hydrolyzing 1 and 2. Although these sapogenin showed strong NO inhibition, these effects were caused by the cytotoxic effect on Raw 264.7 cells. These results supported the notion that buddlejasaponin IV is a major inhibitors of NO, PGE2 and TNF-α production in P. kamtschaticum. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Pharmaceutical Society of Japan | - |
dc.relation.isPartOf | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal/isolation & purification* | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal/pharmacology* | - |
dc.subject.MESH | Apiaceae/chemistry* | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Dinoprostone/antagonists & inhibitors* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lipopolysaccharides/antagonists & inhibitors | - |
dc.subject.MESH | Lipopolysaccharides/toxicity | - |
dc.subject.MESH | Macrophages/drug effects | - |
dc.subject.MESH | Macrophages/metabolism | - |
dc.subject.MESH | Nitric Oxide/antagonists & inhibitors* | - |
dc.subject.MESH | Plant Extracts/pharmacology | - |
dc.subject.MESH | Prostaglandin Antagonists* | - |
dc.subject.MESH | Sapogenins/isolation & purification | - |
dc.subject.MESH | Sapogenins/pharmacology | - |
dc.subject.MESH | Saponins/isolation & purification* | - |
dc.subject.MESH | Saponins/pharmacology* | - |
dc.subject.MESH | Tetrazolium Salts | - |
dc.subject.MESH | Thiazoles | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/antagonists & inhibitors* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/biosynthesis* | - |
dc.title | Isolation of Saponins with the Inhibitory Effect on Nitric Oxide, Prostaglandin E2 and Tumor Necrosis Factor-α Production from Pleurospermum kamtschaticum | - |
dc.type | Article | - |
dc.publisher.location | Japan | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Hyun-Ju Jung | - |
dc.contributor.googleauthor | Sei-Gun Kim | - |
dc.contributor.googleauthor | Jung-Hwan Nam | - |
dc.contributor.googleauthor | Kwang-Kyun Park | - |
dc.contributor.googleauthor | Won-Yun Chung | - |
dc.contributor.googleauthor | Won-Bae Kim | - |
dc.contributor.googleauthor | Kyung-Tae Lee | - |
dc.contributor.googleauthor | Jong-Heon Won | - |
dc.contributor.googleauthor | Jong-Won Choi | - |
dc.contributor.googleauthor | Hee-Juhn Park | - |
dc.identifier.doi | 10.1248/bpb.28.1668 | - |
dc.contributor.localId | A01429 | - |
dc.contributor.localId | A03676 | - |
dc.relation.journalcode | J00300 | - |
dc.identifier.eissn | 1347-5215 | - |
dc.identifier.pmid | 16141537 | - |
dc.subject.keyword | Pleurospermum kamtschaticum | - |
dc.subject.keyword | Umbelliferae | - |
dc.subject.keyword | saponin | - |
dc.subject.keyword | nitric oxide | - |
dc.subject.keyword | prostaglandin E2 | - |
dc.subject.keyword | tumor necrosis factor-α | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.alternativeName | Chung, Won Yoon | - |
dc.contributor.affiliatedAuthor | 박광균 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1668 | - |
dc.citation.endPage | 1671 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, Vol.28(9) : 1668-1671, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 44080 | - |
dc.type.rims | ART | - |
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