Cited 6 times in
Different role of functional domains of hTR in DNA binding to telomere and telomerase reconstruction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 심웅호 | - |
dc.contributor.author | 안성환 | - |
dc.contributor.author | 양상화 | - |
dc.contributor.author | 여말희 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 정희철 | - |
dc.date.accessioned | 2017-10-26T06:44:19Z | - |
dc.date.available | 2017-10-26T06:44:19Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151234 | - |
dc.description.abstract | Even if template sequence of hTR played an essential role in telomere binding, a 326 nucleotide fragment of hTR containing template, pseudoknot, and CR4–5 domains is critical for both binding with telomeric DNA and reconstitution of telomerase activity. A functional study with antisense oligonucleotides suggested that targeted disruption of the template region efficiently abrogated both telomeric DNA binding and telomerase activity, whereas disruption of the CR4–5 region induced only loss of telomerase activity. hTR interacts with telomeric DNA via structural region composed of the template, pseudoknot, and CR4–5 domains, however, each structural domain plays a distinct role in telomere binding and telomerase activity reconstitution. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Binding Sites | - |
dc.subject.MESH | DNA/drug effects | - |
dc.subject.MESH | DNA/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoprecipitation | - |
dc.subject.MESH | Mutation/genetics | - |
dc.subject.MESH | Nucleic Acid Conformation | - |
dc.subject.MESH | Oligonucleotides, Antisense/genetics | - |
dc.subject.MESH | Oligonucleotides, Antisense/pharmacology | - |
dc.subject.MESH | RNA | - |
dc.subject.MESH | RNA, Long Noncoding | - |
dc.subject.MESH | RNA, Untranslated/chemistry* | - |
dc.subject.MESH | RNA, Untranslated/genetics | - |
dc.subject.MESH | RNA, Untranslated/metabolism* | - |
dc.subject.MESH | Telomerase/chemistry* | - |
dc.subject.MESH | Telomerase/genetics | - |
dc.subject.MESH | Telomerase/metabolism* | - |
dc.subject.MESH | Telomere/metabolism* | - |
dc.subject.MESH | Templates, Genetic | - |
dc.title | Different role of functional domains of hTR in DNA binding to telomere and telomerase reconstruction | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | Research Institutes (연구소) | - |
dc.contributor.college | Research Institutes (연구소) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.department | Cancer Metastasis Research Center (암전이연구센터) | - |
dc.contributor.department | Cancer Metastasis Research Center (암전이연구센터) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | M. Yeo | - |
dc.contributor.googleauthor | S.Y. Rha | - |
dc.contributor.googleauthor | H.C. Jeung | - |
dc.contributor.googleauthor | X.H. Shen | - |
dc.contributor.googleauthor | S.H. Yang | - |
dc.contributor.googleauthor | S.W. An | - |
dc.contributor.googleauthor | J.K. Roh | - |
dc.contributor.googleauthor | H.C. Chung | - |
dc.identifier.doi | 10.1016/j.febslet.2004.11.058 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A02201 | - |
dc.contributor.localId | A02239 | - |
dc.contributor.localId | A02288 | - |
dc.contributor.localId | A02345 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A03794 | - |
dc.relation.journalcode | J00890 | - |
dc.identifier.eissn | 1873-3468 | - |
dc.identifier.pmid | 15620701 | - |
dc.subject.keyword | Telomere | - |
dc.subject.keyword | hTR | - |
dc.subject.keyword | Pseudoknot | - |
dc.subject.keyword | CR4–5 | - |
dc.subject.keyword | hTERT | - |
dc.subject.keyword | Telomerase | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Shen, Xiong Hu | - |
dc.contributor.alternativeName | An, Sung Whan | - |
dc.contributor.alternativeName | Yang, Sang Hwa | - |
dc.contributor.alternativeName | Yeo, Marie | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | 노재경 | - |
dc.citation.volume | 579 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 127 | - |
dc.citation.endPage | 132 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, Vol.579(1) : 127-132, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 43956 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.