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세로토닌 수송체 관련 전사체 부위 유전자 다형성과 강박장애 발병 연령과의 관련성
DC Field | Value | Language |
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dc.contributor.author | 김찬형 | - |
dc.contributor.author | 이홍식 | - |
dc.date.accessioned | 2017-10-26T06:31:01Z | - |
dc.date.available | 2017-10-26T06:31:01Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1017-5717 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150912 | - |
dc.description.abstract | Objective: Many researches strongly suggest that early- and late-onset obsessive-compulsive disorder (OCD) represent separate subtypes of the disorder, possibly with distinct underlying pathogeneses. The aim of this study was to determine the association between 5-HTTLPR genotypes and the onset of OCD. Methods: We recruited 124 OCD patients and classified them into an early-onset group (age of onset <18 years) and a late onset-group (age of onset ≥18 years). From the blood, DNA was isolated using standard techniques and the 5-HTTLPR polymorphism was genotyped by polymerase chain reaction and electrophoresis. We classified the subject as s/s, s/l, and l/l group according to their genotype. We also combined the s/l and l/l genotypes (l allele non-carrier) and compared these with the s/s genotype (l allele non-carrier) for our analysis. Genotype and allele frequencies of early- and late-onset OCD were analyzed by chi-square statistics. Results: The frequencies of s/l+ l/l genotype and I allele in early-onset OCD group were significantly higher than late-onset OCD group. Conclusion: These results suggest that a 5-HTTLPR polymorphism is an important factor in the onset of OCD. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한정신약물학회 | - |
dc.relation.isPartOf | Korean Journal of Psychopharmacology (대한정신약물학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Serotonin transporter polymorphism | - |
dc.subject.MESH | Early-onset | - |
dc.subject.MESH | Late-onset | - |
dc.subject.MESH | Obsessive-compulsive disorder | - |
dc.title | 세로토닌 수송체 관련 전사체 부위 유전자 다형성과 강박장애 발병 연령과의 관련성 | - |
dc.title.alternative | Association between Serotonin Transporter Linked Promoter Region(5-HTTLPR) Polymorphism and Age of Onset of Obsessive-Compulsive Disorder | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학교실) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학교실) | - |
dc.contributor.googleauthor | 김세주 | - |
dc.contributor.googleauthor | 김찬형 | - |
dc.contributor.googleauthor | 이홍식 | - |
dc.identifier.doi | OAK-2005-03910 | - |
dc.contributor.localId | A01036 | - |
dc.contributor.localId | A03332 | - |
dc.relation.journalcode | J02107 | - |
dc.identifier.eissn | 2092-5700 | - |
dc.subject.keyword | Serotonin transporter polymorphism | - |
dc.subject.keyword | Early-onset | - |
dc.subject.keyword | Late-onset | - |
dc.subject.keyword | Obsessive-compulsive disorder | - |
dc.contributor.alternativeName | Kim, Chan Hyung | - |
dc.contributor.alternativeName | Lee, Hong Shick | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 76 | - |
dc.citation.endPage | 80 | - |
dc.identifier.bibliographicCitation | Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.16(1) : 76-80, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42763 | - |
dc.type.rims | ART | - |
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