Cited 848 times in
In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경섭 | - |
dc.contributor.author | 김성준 | - |
dc.contributor.author | 서진석 | - |
dc.contributor.author | 송호택 | - |
dc.contributor.author | 신전수 | - |
dc.contributor.author | 윤사라 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2017-09-30T06:33:30Z | - |
dc.date.available | 2017-09-30T06:33:30Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150033 | - |
dc.description.abstract | The unique properties of magnetic nanocrystals provide them with high potential as key probes and vectors in the next generation of biomedical applications. Although superparamagnetic iron oxide nanocrystals have been extensively studied as excellent magnetic resonance imaging (MRI) probes for various cell trafficking, gene expression, and cancer diagnosis, further development of in vivo MRI applications has been very limited. Here, we describe in vivo diagnosis of cancer, utilizing a well-defined magnetic nanocrystal probe system with multiple capabilities, such as small size, strong magnetism, high biocompatibility, and the possession of active functionality for desired receptors. Our magnetic nanocrystals are conjugated to a cancer-targeting antibody, Herceptin, and subsequent utilization of these conjugates as MRI probes has been successfully demonstrated for the monitoring of in vivo selective targeting events of human cancer cells implanted in live mice. Further conjugation of these nanocrystal probes with fluorescent dye-labeled antibodies enables both in vitro and ex vivo optical detection of cancer as well as in vivo MRI, which are potentially applicable for an advanced multimodal detection system. Our study finds that high performance in vivo MR diagnosis of cancer is achievable by utilizing improved and multifunctional material properties of iron oxide nanocrystal probes. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Monoclonal/chemistry | - |
dc.subject.MESH | Antibodies, Monoclonal, Humanized | - |
dc.subject.MESH | Cell Transplantation | - |
dc.subject.MESH | Crystallization | - |
dc.subject.MESH | Ferric Compounds/chemistry | - |
dc.subject.MESH | Fluorescent Antibody Technique | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Microscopy, Electron | - |
dc.subject.MESH | Molecular Probes* | - |
dc.subject.MESH | Nanostructures/chemistry* | - |
dc.subject.MESH | Neoplasms/diagnosis* | - |
dc.subject.MESH | Spectrometry, Fluorescence | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Trastuzumab | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.department | Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Young-wook Jun | - |
dc.contributor.googleauthor | Ho-Taek Song | - |
dc.contributor.googleauthor | Sungjun Kim | - |
dc.contributor.googleauthor | Jin-sil Choi | - |
dc.contributor.googleauthor | Jae-Hyun Lee | - |
dc.contributor.googleauthor | Sarah Yoon | - |
dc.contributor.googleauthor | Kyung-Sup Kim | - |
dc.contributor.googleauthor | Jeon-Soo Shin | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Jinwoo Cheon | - |
dc.identifier.doi | 10.1021/ja052337c | - |
dc.contributor.localId | A00297 | - |
dc.contributor.localId | A00585 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02080 | - |
dc.contributor.localId | A02144 | - |
dc.contributor.localId | A02557 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J01769 | - |
dc.identifier.eissn | 1520-5126 | - |
dc.identifier.pmid | 16131220 | - |
dc.identifier.url | http://pubs.acs.org/doi/abs/10.1021/ja052337c | - |
dc.subject.keyword | 16131220 | - |
dc.contributor.alternativeName | Kim, Kyung Sup | - |
dc.contributor.alternativeName | Kim, Sung Jun | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Song, Ho Taek | - |
dc.contributor.alternativeName | Shin, Jeon Soo | - |
dc.contributor.alternativeName | Yoon, Sa Rah | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.citation.volume | 127 | - |
dc.citation.number | 35 | - |
dc.citation.startPage | 12387 | - |
dc.citation.endPage | 12391 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.127(35) : 12387-12391, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42715 | - |
dc.type.rims | ART | - |
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