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The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate
DC Field | Value | Language |
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dc.contributor.author | 유영훈 | - |
dc.contributor.author | 천근아 | - |
dc.date.accessioned | 2017-09-30T06:30:33Z | - |
dc.date.available | 2017-09-30T06:30:33Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0924-977X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/149983 | - |
dc.description.abstract | The symptoms of attention deficit hyperactivity disorder (ADHD) can be treated with methylphenidate (MPH), a potent blocker of dopamine transporter (DAT). The homozygosity of the 10-repeat allele at the DAT gene (DAT1) seems to be associated with a poor response to MPH in children with ADHD. In the present study, we investigated the association between DAT density using I-123-N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane [123I]IPT single photon emission computed tomography (SPECT)] and the homozygosity for 10-repeat allele at DAT1 and response to MPH in Korean children with ADHD. Eleven drug-naive children with ADHD were included in the study and treated with MPH for about 8 weeks. After the genotyping and SPECT were performed, we compared DAT density between ADHD children with and without the homozygosity for 10-repeat allele at DAT1 and investigated the correlation between the homozygosity for 10-repeat allele and response to MPH. ADHD children with 10/10 genotype (n=7) had a significantly greater increase of the DAT density in basal ganglia than the children without 10/10 genotype (n=4). We found that while only 28.6% (2/7) of the subject with 10/10 genotype showed good response to MPH treatment, 100% (4/4) of the subjects without 10/10 genotype showed good response to MPH treatment. Our findings support an association between homozygosity for 10-repeat allele at DAT1 and the DAT density assessed in vivo and correlation between the homozygosity for 10-repeat allele and poor response to MPH. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | EUROPEAN NEUROPSYCHOPHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Korean children with ADHD | - |
dc.subject.MESH | Dopamine transporter gene | - |
dc.subject.MESH | Dopamine transporter density | - |
dc.subject.MESH | Response to methylphenidate | - |
dc.title | The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학교실) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학교실) | - |
dc.contributor.googleauthor | Keun-Ah Cheon | - |
dc.contributor.googleauthor | Young-Hoon Ryu | - |
dc.contributor.googleauthor | Jae-Won Kim | - |
dc.contributor.googleauthor | Dae-Yeon Cho | - |
dc.identifier.doi | 10.1016/j.euroneuro.2004.06.004 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A04027 | - |
dc.relation.journalcode | J00850 | - |
dc.identifier.eissn | 1873-7862 | - |
dc.identifier.pmid | 10.1016/j.euroneuro.2004.06.004 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0924977X04000963 | - |
dc.subject.keyword | Korean children with ADHD | - |
dc.subject.keyword | Dopamine transporter gene | - |
dc.subject.keyword | Dopamine transporter density | - |
dc.subject.keyword | Response to methylphenidate | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.alternativeName | Cheon, Keun Ah | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 101 | - |
dc.identifier.bibliographicCitation | EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol.15(1) : 95-101, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42056 | - |
dc.type.rims | ART | - |
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