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TNF-α induced pro-inflammation stimulates apolipoprotein-A4 via activation of a TNFR2 and NF-κB signaling pathway in kidney tubular cell
DC Field | Value | Language |
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dc.contributor.author | 조영인 | - |
dc.date.accessioned | 2017-07-11T16:10:22Z | - |
dc.date.available | 2017-07-11T16:10:22Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/149144 | - |
dc.description | Dept. of Medical Science/석사 | - |
dc.description.abstract | Acute kidney injury (AKI) is the initial stage of kidney disease and can lead to chronic kidney disease (CKD). Human apolipoprotein A4 (apo-A4) levels are significantly elevated in early-stage CKD. Moreover, elevated apo-A4 levels in the kidney lead to abnormal apo-A4 protein deposits in body tissues and organs, which can cause amyloidosis. Therefore, apo-A4 regulation can affect cell viability following kidney injury. To determine which types of AKI affect apo-A4 levels, we induced AKI in human kidney cells using a variety of conditions. Apo-A4 expression level was only affected by Tumor necrosis factor alpha (TNF-α) treatment. Our data showed that pro-inflammatory AKI caused by TNF-α induced TNFR2 activation via NF-ĸB and enhanced apo-A4 expression in human kidney cells and tissues. Moreover, apo-a4 overexpression affected the recovery of kidney cells. In conclusion, apo-A4 expression was upregulated by TNF-α. In addition, we showed that inflammatory kidney damage occurs through a TNFR2-NFĸB complex and that apo-A4 regulation can affect cell viability | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | TNF-α induced pro-inflammation stimulates apolipoprotein-A4 via activation of a TNFR2 and NF-κB signaling pathway in kidney tubular cell | - |
dc.title.alternative | TNF-α로 유도된 염증반응에서 apolipoprotein-A4는 TNFR2와 NF-κB 경로를 통해 촉진된다 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Cho, Young in | - |
dc.type.local | Thesis | - |
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