Cited 26 times in
Chromosomal imbalances in Korean intrahepatic cholangiocarcinoma by comparative genomic hybridization
DC Field | Value | Language |
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dc.contributor.author | 박영년 | - |
dc.contributor.author | 윤동섭 | - |
dc.date.accessioned | 2017-05-04T07:36:55Z | - |
dc.date.available | 2017-05-04T07:36:55Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0165-4608 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147543 | - |
dc.description.abstract | Intrahepatic cholangiocarcinoma (ICC) arises from epithelial cells in the intrahepatic bile duct. Until now, only few reports have been available concerning the genetic changes during the progression of ICC. In this study, we analyzed chromosomal aberrations in 19 frozen ICC samples using comparative genomic hybridization. The common chromosomal gains were observed in 8q22∼qter (11 cases, 58%), 5p14∼pter (32%), 2q33∼qter (26%), 7p (26%), 17q21∼q22 (26%), 18q12∼q21 (26%), and 19q13.1 (26%). DNA amplification was identified in nine tumors (47%). Chromosomal loss was found in Y (60%), 1p34∼pter (37%), 4q(32%), 18q21∼qter (32%) 19p (32%), X (32%), 5q11∼q14 (26%), 8p(26%), 9p (26%), and 17p (26%). Chromosomal aberrations identified in this study provide candidate regions involved in the tumorigenesis and progression of ICC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier/North-Holland | - |
dc.relation.isPartOf | CANCER GENETICS AND CYTOGENETICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Bile Duct Neoplasms/genetics* | - |
dc.subject.MESH | Bile Ducts, Intrahepatic* | - |
dc.subject.MESH | Cholangiocarcinoma/genetics* | - |
dc.subject.MESH | Chromosome Aberrations* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nucleic Acid Hybridization/methods* | - |
dc.title | Chromosomal imbalances in Korean intrahepatic cholangiocarcinoma by comparative genomic hybridization | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Kyung-Ok Uhm | - |
dc.contributor.googleauthor | Young-Nyun Park | - |
dc.contributor.googleauthor | Ji-Young Lee | - |
dc.contributor.googleauthor | Dong-Seop Yoon | - |
dc.contributor.googleauthor | Sun-Hwa Park | - |
dc.identifier.doi | 10.1016/j.cancergencyto.2004.05.007 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A02548 | - |
dc.relation.journalcode | J00443 | - |
dc.identifier.eissn | 1873-4456 | - |
dc.identifier.pmid | 15676145 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0165460804002316 | - |
dc.subject.keyword | 15676145 | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Yoon, Dong Sup | - |
dc.citation.volume | 157 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 37 | - |
dc.citation.endPage | 41 | - |
dc.identifier.bibliographicCitation | CANCER GENETICS AND CYTOGENETICS , Vol.157(1) : 37-41, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 40318 | - |
dc.type.rims | ART | - |
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