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Prognostic significance of DNA quantification by flow cytometry in ovarian tumors

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dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author김재욱-
dc.contributor.author김재훈-
dc.date.accessioned2017-05-04T07:32:16Z-
dc.date.available2017-05-04T07:32:16Z-
dc.date.issued2005-
dc.identifier.issn0020-7292-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147428-
dc.description.abstractOBJECTIVE: The objective of our study is to evaluate prognostic significance of DNA quantification by flow cytometry in ovarian tumor. METHODS: A prospective analysis was performed on 56 ovarian tumor patients treated in the Yonsei Medical Center from Feb. 2000 to Jan. 2003. RESULTS: Regarding the association between tumor grade and the DNA quantitative analysis, as tumor grade increased, the quantity of aneuploid cells and S-phase fraction (SPF) increased. In addition, SPF was increased significantly in the advanced staged patients (P=0.04) and SPF was significantly increased in aneuploid tumors (P=0.03). The overall survival rate was poor for patients with aneuploid tumors and for patients with tumors showing over SPF (10%). CONCLUSION: Our data demonstrated that the prognosis was poor for patients with aneuploid cancers or increased SPF. Therefore, DNA quantification by flow cytometry may provide important information for predicting the prognosis of the disease.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAneuploidy-
dc.subject.MESHDNA, Neoplasm/genetics*-
dc.subject.MESHDiploidy-
dc.subject.MESHFemale-
dc.subject.MESHFlow Cytometry-
dc.subject.MESHHumans-
dc.subject.MESHOvarian Neoplasms/mortality*-
dc.subject.MESHPloidies*-
dc.subject.MESHPregnancy-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHS Phase/genetics-
dc.subject.MESHSurvival Analysis-
dc.titlePrognostic significance of DNA quantification by flow cytometry in ovarian tumors-
dc.typeArticle-
dc.publisher.locationIreland-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorY.T. Kim-
dc.contributor.googleauthorM. Zhao-
dc.contributor.googleauthorS.H. Kim-
dc.contributor.googleauthorC.S. Lee-
dc.contributor.googleauthorJ.H. Kim-
dc.contributor.googleauthorJ.W. Kim-
dc.identifier.doi10.1016/j.ijgo.2004.12.010-
dc.contributor.localIdA00595-
dc.contributor.localIdA00729-
dc.contributor.localIdA00866-
dc.contributor.localIdA00876-
dc.relation.journalcodeJ01117-
dc.identifier.eissn1879-3479-
dc.identifier.pmid15733883-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0020729204004989-
dc.subject.keywordOvarian tumor-
dc.subject.keywordPrognostic factor-
dc.subject.keywordDNA ploidy-
dc.subject.keywordS-phase fraction-
dc.subject.keywordCA-125-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.alternativeNameKim, Jae Wook-
dc.contributor.alternativeNameKim, Jae Hoon-
dc.citation.volume88-
dc.citation.number3-
dc.citation.startPage286-
dc.citation.endPage291-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, Vol.88(3) : 286-291, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid40211-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
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