Cited 25 times in
Estimated Trans-Lamina Cribrosa Pressure Differences in Low-Teen and High-Teen Intraocular Pressure Normal Tension Glaucoma: The Korean National Health and Nutrition Examination Survey
DC Field | Value | Language |
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dc.contributor.author | 강은민 | - |
dc.contributor.author | 김규아 | - |
dc.contributor.author | 김찬윤 | - |
dc.contributor.author | 배형원 | - |
dc.contributor.author | 성공제 | - |
dc.contributor.author | 이상엽 | - |
dc.contributor.author | 이시형 | - |
dc.date.accessioned | 2017-02-24T11:40:10Z | - |
dc.date.available | 2017-02-24T11:40:10Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146828 | - |
dc.description.abstract | BACKGROUND: To investigate the association between estimated trans-lamina cribrosa pressure difference (TLCPD) and prevalence of normal tension glaucoma (NTG) with low-teen and high-teen intraocular pressure (IOP) using a population-based study design. METHODS: A total of 12,743 adults (≥ 40 years of age) who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) from 2009 to 2012 were included. Using a previously developed formula, cerebrospinal fluid pressure (CSFP) in mmHg was estimated as 0.55 × body mass index (kg/m2) + 0.16 × diastolic blood pressure (mmHg)-0.18 × age (years)-1.91. TLCPD was calculated as IOP-CSFP. The NTG subjects were divided into two groups according to IOP level: low-teen NTG (IOP ≤ 15 mmHg) and high-teen NTG (15 mmHg < IOP ≤ 21 mmHg) groups. The association between TLCPD and the prevalence of NTG was assessed in the low- and high-teen IOP groups. RESULTS: In the normal population (n = 12,069), the weighted mean estimated CSFP was 11.69 ± 0.04 mmHg and the weighted mean TLCPD 2.31 ± 0.06 mmHg. Significantly higher TLCPD (p < 0.001; 6.48 ± 0.27 mmHg) was found in the high-teen NTG compared with the normal group. On the other hand, there was no significant difference in TLCPD between normal and low-teen NTG subjects (p = 0.395; 2.31 ± 0.06 vs. 2.11 ± 0.24 mmHg). Multivariate logistic regression analysis revealed that TLCPD was significantly associated with the prevalence of NTG in the high-teen IOP group (p = 0.006; OR: 1.09; 95% CI: 1.02, 1.15), but not the low-teen IOP group (p = 0.636). Instead, the presence of hypertension was significantly associated with the prevalence of NTG in the low-teen IOP group (p < 0.001; OR: 1.65; 95% CI: 1.26, 2.16). CONCLUSIONS: TLCPD was significantly associated with the prevalence of NTG in high-teen IOP subjects, but not low-teen IOP subjects, in whom hypertension may be more closely associated. This study suggests that the underlying mechanisms may differ between low-teen and high-teen NTG patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e0148412 | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Blood Pressure* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glaucoma/epidemiology | - |
dc.subject.MESH | Glaucoma/physiopathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension/epidemiology | - |
dc.subject.MESH | Hypertension/physiopathology* | - |
dc.subject.MESH | Intraocular Pressure* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.title | Estimated Trans-Lamina Cribrosa Pressure Differences in Low-Teen and High-Teen Intraocular Pressure Normal Tension Glaucoma: The Korean National Health and Nutrition Examination Survey | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Ophthalmology | - |
dc.contributor.googleauthor | Si Hyung Lee | - |
dc.contributor.googleauthor | Seung Woo Kwak | - |
dc.contributor.googleauthor | Eun Min Kang | - |
dc.contributor.googleauthor | Gyu Ah Kim | - |
dc.contributor.googleauthor | Sang Yeop Lee | - |
dc.contributor.googleauthor | Hyoung Won Bae | - |
dc.contributor.googleauthor | Gong Je Seong | - |
dc.contributor.googleauthor | Chan Yun Kim | - |
dc.identifier.doi | 10.1371/journal.pone.0148412 | - |
dc.contributor.localId | A00067 | - |
dc.contributor.localId | A00326 | - |
dc.contributor.localId | A01035 | - |
dc.contributor.localId | A01814 | - |
dc.contributor.localId | A01946 | - |
dc.contributor.localId | A02820 | - |
dc.contributor.localId | A04630 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 26840184 | - |
dc.contributor.alternativeName | Kang, Eun Min | - |
dc.contributor.alternativeName | Kim, Gyuah | - |
dc.contributor.alternativeName | Kim, Chan Yun | - |
dc.contributor.alternativeName | Bae, Hyoung Won | - |
dc.contributor.alternativeName | Seong, Gong Je | - |
dc.contributor.alternativeName | Lee, Sang Yeop | - |
dc.contributor.alternativeName | Lee, Si Hyung | - |
dc.contributor.affiliatedAuthor | Kang, Eun Min | - |
dc.contributor.affiliatedAuthor | Kim, Gyuah | - |
dc.contributor.affiliatedAuthor | Kim, Chan Yun | - |
dc.contributor.affiliatedAuthor | Bae, Hyoung Won | - |
dc.contributor.affiliatedAuthor | Seong, Gong Je | - |
dc.contributor.affiliatedAuthor | Lee, Sang Yeop | - |
dc.contributor.affiliatedAuthor | Lee, Si Hyung | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e0148412 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.11(2) : e0148412, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47570 | - |
dc.type.rims | ART | - |
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