Cited 4 times in
Novel insights into a retinoic-acid-induced cleft palate based on Rac1 regulation of the fibronectin arrangement
DC Field | Value | Language |
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dc.contributor.author | 이종민 | - |
dc.contributor.author | 정한성 | - |
dc.date.accessioned | 2017-02-24T03:40:14Z | - |
dc.date.available | 2017-02-24T03:40:14Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0302-766X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146412 | - |
dc.description.abstract | Retinoic acid (RA)-induced cleft palate results from both extrinsic obstructions by the tongue and internal factors within the palatal shelves. Our previous study showed that the spatiotemporal expression of Rac1 regulates the fibronectin (FN) arrangement through cell density alterations that play an important role in palate development. In this study, we investigate the involvement of the Rac1 regulation of the FN arrangement in RA-induced cleft palate. Our results demonstrate that RA-induced intrinsic alterations in palatal shelves, including a delayed progress of cell condensation, delay palate development, even after the removal of the tongue. Further analysis shows that RA treatment diminishes the region-distinctive expression of Rac1 within the palatal shelves, which reversely alters the fibrillar arrangement of FN. Furthermore, RA treatment disrupts the formation of lamellipodia, which are indicative structures of cell migration that are regulated by Rac1. These results suggest that the Rac1 regulation of the FN arrangement is involved in RA-induced cleft palate through the regulation of cell migration, which delays the progress of cell condensation and subsequently influences the FN arrangement, inducing a delay in palate development. Our study provides new insights into the RA-induced impairment of palatal shelf elevation based on cell migration dynamics. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 713~722 | - |
dc.language | English | - |
dc.publisher | Springer-Verlag | - |
dc.relation.isPartOf | CELL AND TISSUE RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Count | - |
dc.subject.MESH | Cleft Palate/chemically induced* | - |
dc.subject.MESH | Cleft Palate/metabolism* | - |
dc.subject.MESH | Fibronectins/metabolism* | - |
dc.subject.MESH | Mesoderm/pathology | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Palate/metabolism | - |
dc.subject.MESH | Palate/pathology | - |
dc.subject.MESH | Pseudopodia/metabolism | - |
dc.subject.MESH | Tongue | - |
dc.subject.MESH | Tretinoin | - |
dc.subject.MESH | rac1 GTP-Binding Protein/metabolism* | - |
dc.title | Novel insights into a retinoic-acid-induced cleft palate based on Rac1 regulation of the fibronectin arrangement | - |
dc.type | Article | - |
dc.publisher.location | Germany | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dep. of Oral Biology, Oral Science Research Center | - |
dc.contributor.googleauthor | Qinghuang Tang | - |
dc.contributor.googleauthor | Liwen Li | - |
dc.contributor.googleauthor | Min-Jung Lee | - |
dc.contributor.googleauthor | Qing Ge | - |
dc.contributor.googleauthor | Jong-Min Lee | - |
dc.contributor.googleauthor | Han-Sung Jung | - |
dc.identifier.doi | 10.1007/s00441-015-2271-z | - |
dc.contributor.localId | A04640 | - |
dc.contributor.localId | A03758 | - |
dc.relation.journalcode | J00474 | - |
dc.identifier.eissn | 1432-0878 | - |
dc.identifier.pmid | 26329303 | - |
dc.identifier.url | http://link.springer.com/article/10.1007/s00441-015-2271-z | - |
dc.subject.keyword | Cleft palate | - |
dc.subject.keyword | Fibronectin | - |
dc.subject.keyword | Mouse | - |
dc.subject.keyword | Palatal shelf elevation | - |
dc.subject.keyword | Rac1 | - |
dc.subject.keyword | Retinoic acid | - |
dc.contributor.alternativeName | Lee, Jong Min | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Lee, Jong Min | - |
dc.contributor.affiliatedAuthor | Jung, Han Sung | - |
dc.citation.volume | 363 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 713 | - |
dc.citation.endPage | 722 | - |
dc.identifier.bibliographicCitation | CELL AND TISSUE RESEARCH, Vol.363(3) : 713-722, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47920 | - |
dc.type.rims | ART | - |
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