Cited 52 times in
Prognostic value of vascular endothelial growth factor in stage IB carcinoma of the uterine cervix
DC Field | Value | Language |
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dc.contributor.author | 이익재 | - |
dc.date.accessioned | 2016-05-16T11:30:43Z | - |
dc.date.available | 2016-05-16T11:30:43Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144713 | - |
dc.description.abstract | PURPOSE: To clarify the role of vascular endothelial growth factor (VEGF) expression as an independent prognostic factor in Stage IB cervical cancer. METHODS AND MATERIALS: A total of 117 patients with Stage IB cervical cancer who had undergone radical hysterectomy and pelvic lymph node dissection with complete histopathologic examination were included. Eighty-eight (75.2%) patients received postoperative radiotherapy and/or chemotherapy. VEGF expression was examined using immunohistochemistry. RESULTS: Of 117 patients, 35 (29.9%) showed high-intensity VEGF expression and 69 (59%) had a high score for area of VEGF expression. Strong correlations were found between high VEGF intensity and both deep stromal invasion (p = 0.01) and positive pelvic lymph nodes (p = 0.03). The area of VEGF expression was significantly associated with tumor size (p = 0.02). In a multivariate analysis, high VEGF intensity (p = 0.009) and tumor size (p = 0.01) were significant prognostic factors for overall survival and disease-free survival (p = 0.001 and p = 0.003, respectively). However, the area of VEGF expression was not a prognostic factor for overall survival or disease-free survival. CONCLUSION: Our findings on the correlation between VEGF expression and prognosis were conflicting. Functional and quantitative tools to assess tumor angiogenesis in addition to the expression of VEGF need to be developed and would be helpful to support the finding that tumor angiogenesis correlates significantly with prognosis in early-stage cervical cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 768~779 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/chemistry* | - |
dc.subject.MESH | Adenocarcinoma/mortality | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Carcinoma, Adenosquamous/chemistry* | - |
dc.subject.MESH | Carcinoma, Adenosquamous/mortality | - |
dc.subject.MESH | Carcinoma, Adenosquamous/pathology | - |
dc.subject.MESH | Carcinoma, Squamous Cell/chemistry* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/mortality | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology | - |
dc.subject.MESH | Endothelial Growth Factors/analysis* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intercellular Signaling Peptides and Proteins/analysis* | - |
dc.subject.MESH | Lymphokines/analysis* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Proteins/analysis* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Treatment Failure | - |
dc.subject.MESH | Uterine Cervical Neoplasms/chemistry* | - |
dc.subject.MESH | Uterine Cervical Neoplasms/mortality | - |
dc.subject.MESH | Uterine Cervical Neoplasms/pathology | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A | - |
dc.subject.MESH | Vascular Endothelial Growth Factors | - |
dc.title | Prognostic value of vascular endothelial growth factor in stage IB carcinoma of the uterine cervix | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Ik Jae Lee | - |
dc.contributor.googleauthor | Kyung Ran Park | - |
dc.contributor.googleauthor | Kang Kyoo Lee | - |
dc.contributor.googleauthor | Ji Sun Song | - |
dc.contributor.googleauthor | Kwang Gil Lee | - |
dc.contributor.googleauthor | Jong Young Lee | - |
dc.contributor.googleauthor | Dong Soo Cha | - |
dc.contributor.googleauthor | Hyun Il Choi | - |
dc.contributor.googleauthor | Dong Hee Kim | - |
dc.contributor.googleauthor | Young Kun Deung | - |
dc.identifier.doi | 10.1016/S0360-3016(02)02970-X | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03055 | - |
dc.relation.journalcode | J01157 | - |
dc.identifier.eissn | 1879-355X | - |
dc.identifier.pmid | 12377329 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S036030160202970X | - |
dc.subject.keyword | Uterine cervical cancer | - |
dc.subject.keyword | Vascular endothelial growth factor | - |
dc.subject.keyword | Prognostic factor | - |
dc.contributor.alternativeName | Lee, Ik Jae | - |
dc.contributor.affiliatedAuthor | Lee, Ik Jae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 54 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 768 | - |
dc.citation.endPage | 779 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.54(3) : 768-779, 2002 | - |
dc.identifier.rimsid | 51392 | - |
dc.type.rims | ART | - |
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