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Treponema lecithinolyticum 주외막단백질 (MspTL)의 역할 규명

Other Titles
 Functional Characterization of the Major Outer Membrane Protein (MspTL) of Treponema lecithinolyticum 
Authors
 Chong Kwan Kim  ;  Yun Jung Yoo  ;  Young Ho Kim  ;  Bong Kyu Choi 
Citation
 Journal of Bacteriology and Virology, Vol.32(1) : 47-54, 2002 
Journal Title
Journal of Bacteriology and Virology
ISSN
 1225-2344 
Issue Date
2002
Keywords
Periodontitis ; Treponema lecithinolyticum ; Major surface protein
Abstract
Treponema lecithinolyticum is known to be associated with rapidly progressive periodontitis. The full-length gene encoding the major surface protein MspTL of this organism was cloned and expressed by using the expression vector pQE30. Recombinant MspTL(rMspTL) protein was purified and functionally characterized. MspTL was one of several T. lecithinolyticum surface proteins that bound to cultured human gingival fibroblasts (HGFs). As well, it strongly induced IL-6 production by HGFs. These observations suggest that MspTL contributes to pathogenesis of periodontitis by adhesion to host cells and by induction of the proinflammatory cytokine IL-6.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Yoo, Yun Jung(유윤정) ORCID logo https://orcid.org/0000-0002-0045-9597
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144654
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