Cited 9 times in
Clinical characteristics, GAD antibody (GADA) and change of C-peptide in Korean young age of onset diabetic patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안철우 | - |
dc.date.accessioned | 2016-05-16T11:24:11Z | - |
dc.date.available | 2016-05-16T11:24:11Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0742-3071 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144471 | - |
dc.description.abstract | Aims To investigate the association of clinical and immunological markers with diabetes classification in newly diagnosed young diabetic patients at disease onset. Methods Eighty-two diabetic patients recruited within 1 year of onset (mean age 23.0 ± 7.1, M:F = 46:36) were divided into three groups, namely: a low fasting C-peptide (FC) level at baseline group (the low FC group (n = 14, FC < 0.18 nmol/l)), an intermediate FC group (n = 29, 0.18 nmol/l ≤ FC < 0.37 nmol/l), and a high FC group (n = 39, 0.37 nmol/l ≤ FC). Patients were reclassified at follow-up (mean follow-up period 3.7 ± 1.4 years) in the same manner as described above into low FC group (n = 31), intermediate FC group (n = 20), and high FC group (n = 31). The clinical characteristics and prevalence of GADA were compared. Results Patients in the high FC group at baseline had a higher body mass index (BMI), a higher frequency of a family history of diabetes, a higher meal-stimulated C-peptide increment, a lower frequency of ketonuria, a lower frequency of history of diabetic ketoacidosis, and a lower frequency of insulin therapy at diagnosis than those in the low and intermediate FC groups at baseline. Insulin secretory capacity, which was represented by fasting C-peptide, was affected by BMI at diagnosis and the presence of GADA. All the patients of the low FC group on follow-up were finally classified as having Type 1 diabetes; moreover, the factors that determined the type of diabetes were lower BMI at onset, GADA positivity, insulin therapy, lower fasting C-peptide level and lower meal-stimulated C-peptide increment at initial admission. Conclusions Our study suggests that follow-up involving C-peptide and GADA measurements in combination with clinical characteristics is useful for discriminating between the types of diabetes in these groups. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 227~233 | - |
dc.relation.isPartOf | DIABETIC MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age of Onset | - |
dc.subject.MESH | Asian Continental Ancestry Group | - |
dc.subject.MESH | Autoantibodies/blood* | - |
dc.subject.MESH | Blood Glucose/metabolism | - |
dc.subject.MESH | C-Peptide/blood* | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/blood | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/drug therapy | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/immunology* | - |
dc.subject.MESH | Fasting | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glutamate Decarboxylase/immunology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin/therapeutic use | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.title | Clinical characteristics, GAD antibody (GADA) and change of C-peptide in Korean young age of onset diabetic patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | C. W. Ahn | - |
dc.contributor.googleauthor | H. S. Kim | - |
dc.contributor.googleauthor | J. H. Nam | - |
dc.contributor.googleauthor | Y. D. Song | - |
dc.contributor.googleauthor | S. K. Lim | - |
dc.contributor.googleauthor | K. R. Kim | - |
dc.contributor.googleauthor | H. C. Lee | - |
dc.contributor.googleauthor | K. B. Huh | - |
dc.identifier.doi | 10.1046/j.1464-5491.2002.00670.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02270 | - |
dc.relation.journalcode | J00726 | - |
dc.identifier.eissn | 1464-5491 | - |
dc.identifier.pmid | 11918625 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1046/j.1464-5491.2002.00670.x/abstract | - |
dc.subject.keyword | Korean | - |
dc.subject.keyword | young age onset diabetes | - |
dc.subject.keyword | C‐peptide | - |
dc.subject.keyword | GADA | - |
dc.subject.keyword | Type 1 diabetes | - |
dc.subject.keyword | Type 2 diabetes | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 19 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 227 | - |
dc.citation.endPage | 233 | - |
dc.identifier.bibliographicCitation | DIABETIC MEDICINE, Vol.19(3) : 227-233, 2002 | - |
dc.identifier.rimsid | 49737 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.