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Complete Nucleotide Sequence of KCNE1 in Korean Genome

Authors
 Shin Il Yeo  ;  Su Won Kim  ;  Yoon Nyun Kim  ;  Kwan Hee You  ;  Song Woo Shin  ;  Myoung Hee Kim  ;  Jae Chan Song  ;  Min Yoo 
Citation
 Journal of Experimental & Biomedcal Science (대한의생명과학회지), Vol.8(3) : 185-188, 2002 
Journal Title
Journal of Experimental & Biomedcal Science(대한의생명과학회지)
ISSN
 1738-3226 
Issue Date
2002
Keywords
Long QT syndrome ; QT interval ; KCNE1 ; Nested PCR
Abstract
We have cloned the gene for long QT syndrome in Korean genome and determined its detailed nucleotide sequence. Blood DNAs were isolated from 68 healthy individuals (including males and females) and the genomic DNAs were amplified by PCR method followed by automatic DNA sequencing. Entire sequence of the coding region for KCNE1 was located in exon 3. PCR products were reexamined for the confirmation of KCNE1-specific amplification by nested PCR KCNE1 mRNA was 436 bp. This corresponded to 129 amino acids. There was no recognizable difference between males and females. This study should contribute to the better understanding of long QT syndrome in Korean population.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hee(김명희) ORCID logo https://orcid.org/0000-0001-5652-1452
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144465
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