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The effect of spasticity on cortical somatosensory-evoked potentials: changes of cortical somatosensory-evoked potentials after botulinum toxin type A injection.

Authors
 Eun Sook Park  ;  Chang Il Park  ;  Deog Young Kim  ;  Yong Rae Kim 
Citation
 ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, Vol.83(11) : 1592-1596, 2002 
Journal Title
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
ISSN
 0003-9993 
Issue Date
2002
MeSH
Adolescent ; Adult ; Age Factors ; Botulinum Toxins, Type A/pharmacology ; Botulinum Toxins, Type A/therapeutic use* ; Brain Injuries/complications* ; Cerebral Palsy/complications* ; Child ; Child, Preschool ; Electric Stimulation ; Evoked Potentials, Somatosensory/drug effects* ; Female ; Hemiplegia/complications* ; Humans ; Infant ; Injections, Intramuscular ; Magnetic Resonance Imaging ; Male ; Muscle Spasticity/classification ; Muscle Spasticity/diagnosis ; Muscle Spasticity/drug therapy* ; Muscle Spasticity/etiology ; Neuromuscular Agents/pharmacology ; Neuromuscular Agents/therapeutic use* ; Reaction Time/drug effects ; Severity of Illness Index ; Treatment Outcome
Keywords
Botulinum toxin type A ; Cerebral palsy ; Evoked potentials ; somatosensory ; Rehabilitation ; Spasticity
Abstract
Objective: To evaluate the changes in cortical somatosensory-evoked potentials (SEPs) after botulinum toxin type A injection to determine what effect spasticity has on cortical SEPs. Design: Intervention study and before-after trial. Setting: University-affiliated hospital in Korea. Participants: Twelve children with spastic hemiplegic cerebral palsy (CP), 7 children with spastic diplegic CP, and 8 patients with traumatic brain injury. Intervention: All participants had botulinum toxin type A injected into the muscles of the spastic limb. Main Outcome Measures: SEPs were recorded before and 7 days after the botulinum toxin type A injection. Spasticity of the affected spastic limb was also measured. The short latency and amplitude of waves in SEPs were measured. The SEP results were divided into 3 groups: flat (no evoked potential), abnormal (evoked but delayed in latency), and normal (clear waveform with normal latency). Results: The normal response of cortical SEP increased after injection. The SEPs exhibited more frequent improvement in the limbs, with greater improvement of spasticity in grade (>1.0 grade) and in patients of younger age (<3y) after injection (P<.05). Conclusion: The observed improvement of cortical SEPs with associated reduction of spasticity that occurred after the botulinum toxin type A injection indicates that spasticity itself can be considered a factor affecting cortical SEPs. © 2002 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation
Full Text
http://www.archives-pmr.org/article/S0003-9993(02)00257-5/abstract
DOI
10.1053/apmr.2002.34623
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Deog Young(김덕용) ORCID logo https://orcid.org/0000-0001-7622-6311
Park, Eun Sook(박은숙) ORCID logo https://orcid.org/0000-0002-9144-3063
Park, Chang Il(박창일)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144377
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