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Inhibition of mouse skin tumor promotion by anti-inflammatory diarylheptanoids derived from Alpinia oxyphylla Miquel (Zingiberaceae).

Authors
 K.S. Chun  ;  K.K. Park  ;  J. Lee  ;  M. Kang  ;  Y.J. Surh 
Citation
 ONCOLOGY RESEARCH, Vol.13(1) : 37-45, 2002 
Journal Title
ONCOLOGY RESEARCH
ISSN
 0965-0407 
Issue Date
2002
MeSH
Animals ; Anti-InflammatoryAgents, Non-Steroidal/isolation & purification* ; Anti-InflammatoryAgents, Non-Steroidal/therapeutic use* ; Curcumin/therapeutic use ; Diarylheptanoids/therapeutic use ; Edema/prevention & control ; Ginger* ; Guaiacol/analogs & derivatives* ; Guaiacol/therapeutic use ; Inflammation/drug therapy ; Mice ; Phytotherapy* ; Skin/drug effects ; Skin/pathology* ; SkinNeoplasms/pathology ; SkinNeoplasms/prevention & control*
Keywords
Antitumor pro ; Alpinia oxyphylla Miquel
Abstract
Alpinia oxyphylla Miquel, which belongs to the ginger family (Zingiberaceae), has been used in Oriental herbal medicine. Our recent studies have revealed that the methanolic extract of A. oxyphylla suppresses mouse skin tumor promotion and induces apoptosis in cultured human promyelocytic leukemia cells. In the present work, we have assessed effects of yakuchinone A and yakuchinone B, phenolic diarylheptanoids derived from A. oxyphylla, on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation and epidermal ornithine decarboxylase (ODC) activity as well as on skin tumor promotion in female ICR mice. Thus, topical application of 2 or 6 μmol of the diarylheptanoids prior to each topical dose of TPA significantly ameliorated 7,12-dimethylbenz[a]anthracene-initiated mouse skin tumor formation. In parallel with suppression of tumor promotion, topically applied yakuchinone A and B markedly inhibited TPA-induced epidermal ODC activity and ODC mRNA expression. In another experiment, yakuchinone A and B reduced production of tumor necrosis factor-α in TPA-stimulated mouse skin. Furthermore, both compounds inhibited the TPA-induced expression of cyclooxygenase-2 at both transcriptional and translational levels. These findings indicate that pungent diarylheptanoids from A. oxyphylla Miquel have an antitumor promotional activity that might be related to their anti-inflammatory properties.
Full Text
http://www.ingentaconnect.com/content/cog/or/2002/00000013/00000001/or262?token=004b1712856839b7e41225f4038592c4b674748773b242c51576b3427656c3c6a333f2566a5
DOI
10.3727/096504002108747944
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144344
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