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렛드에서 생애초기 스트레스가 청소년기 약물남용에 미치는 영향

Other Titles
 Effects of Stress Early in Life on Drug Abuse at Adolescent Period in Rats 
Authors
 이서울  ;  김동구 
Citation
 Korean Journal of Stress Research (스트레스연구), Vol.10(2) : 41-50, 2002 
Journal Title
Korean Journal of Stress Research(스트레스연구)
ISSN
 1225-665X 
Issue Date
2002
Keywords
Stress ; Early life ; Drug abuse ; Methamphetamine ; Dextromethorphan ; Adolescent
Abstract
We have previously reported that stress early in life resulted in long-term behavioral and neurochemical alter-ations in later life. In this study, we aimed to examine the effect of stress early in life on drug abuse at adolescent period using experimental animals, Sprague-Dawley rats. We used a 60 times exposure to an inescapable and unpredictable footshock as a stressor, and rats were exposed to the stressor twice on postnatal days (PNDs) 14 and 21. Two different classes of drugs of abuse, methamphetamine and dextromethorphan, were tested in this study. Rats were treated with methamphetamine4 mg/kg/day or dextromeethorphan 40 mg/kg/day intraperitoneally during PND 28-37, and methamphetamine 0.8 mg/kg or dextromethorphan 40 mg/kg was challenged on PND 45 after 7 days of drug free period. Locomotor activity of a rat was measured just after injection of drugs. Two drugs elicited behavioral sensitization which implied abuse liability of drugs. Interestingly, rats with experience of footshock stress early in life showed more increased locomotor activity on the challenging day, reflecting enhanced behavioral sensitization. These data suggest that experience of severe stress early in life can make the organism more susceptible to the drugs of abuse at adolescent period when the habit of abusing drug usually starts.
Files in This Item:
T200204093.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Goo(김동구)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143662
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