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Effective isolation of magnesium lithospermate B and its inhibition of aldose reductase and fibronectin on mesangial cell line

DC Field Value Language
dc.contributor.author안철우-
dc.date.accessioned2016-05-16T11:01:55Z-
dc.date.available2016-05-16T11:01:55Z-
dc.date.issued2002-
dc.identifier.issn0009-2363-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/143635-
dc.description.abstractWe developed an effective isolation method of magnesium lithospermate B from Salviae miltiorrhizae Radix and found for the first time that magnesium lithospermate B shows strong in vitro inhibition (IC50=0.04 μM) of aldose reductase (AR), 2.5 times than that of clinically used epalrestat (IC50=0.1 μM) and accumulation of fibronectin dose dependantly.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1135~1136-
dc.relation.isPartOfCHEMICAL & PHARMACEUTICAL BULLETIN-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAldehyde Reductase/antagonists & inhibitors*-
dc.subject.MESHAldehyde Reductase/metabolism-
dc.subject.MESHAnimals-
dc.subject.MESHCell Line-
dc.subject.MESHDrugs, Chinese Herbal/chemistry-
dc.subject.MESHDrugs, Chinese Herbal/isolation & purification*-
dc.subject.MESHDrugs, Chinese Herbal/pharmacology*-
dc.subject.MESHFibronectins/antagonists & inhibitors*-
dc.subject.MESHFibronectins/metabolism-
dc.subject.MESHGlomerular Mesangium/cytology-
dc.subject.MESHGlomerular Mesangium/drug effects*-
dc.subject.MESHGlomerular Mesangium/enzymology*-
dc.subject.MESHMice-
dc.subject.MESHPlant Extracts-
dc.subject.MESHPlant Roots/chemistry-
dc.subject.MESHSalvia miltiorrhiza-
dc.titleEffective isolation of magnesium lithospermate B and its inhibition of aldose reductase and fibronectin on mesangial cell line-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMankil Jung-
dc.contributor.googleauthorHyun Chul Lee-
dc.contributor.googleauthorChul Woo Ahn-
dc.contributor.googleauthorWhuijung Park-
dc.contributor.googleauthorSunhee Choi-
dc.contributor.googleauthorHanjo Kim-
dc.contributor.googleauthorDonghak Cho-
dc.contributor.googleauthorGeun Taek Lee-
dc.contributor.googleauthorHai Ri Li-
dc.identifier.doi10.1248/cpb.50.1135-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02270-
dc.relation.journalcodeJ00509-
dc.identifier.eissn1347-5223-
dc.identifier.pmid12192155-
dc.subject.keywordmagnesium lithospermate B-
dc.subject.keywordaldose reductase-
dc.subject.keywordfibronectin-
dc.subject.keywordSalviae miltiorrhizae Radix-
dc.subject.keywordantidiabetics-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.rights.accessRightsfree-
dc.citation.volume50-
dc.citation.number8-
dc.citation.startPage1135-
dc.citation.endPage1136-
dc.identifier.bibliographicCitationCHEMICAL & PHARMACEUTICAL BULLETIN, Vol.50(8) : 1135-1136, 2002-
dc.identifier.rimsid38318-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
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