Cited 61 times in
Hepatitis B virus X protein induced expression of interleukin 18: a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection
DC Field | Value | Language |
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dc.contributor.author | 김세종 | - |
dc.contributor.author | 박전한 | - |
dc.date.accessioned | 2016-05-16T11:01:39Z | - |
dc.date.available | 2016-05-16T11:01:39Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143625 | - |
dc.description.abstract | Background/Aims: The hepatitis B virus X protein (HBx), a major viral transactivator, is implicated in hepatic inflammation, since it induces many pro-inflammatory cytokines at transcriptional level. The aim of this study was to investigate role of HBx in expression of interleukin 18 (IL-18), a newly identified cytokine that up-regulates Fas ligand (FasL) expression. Methods: Chang X-34 that expressing HBx under the control of a doxycycline-inducible promoter, and hepatitis B virus (HBV)-integrated hepatoma cell lines were examined for IL-18 expression by Northern and Western blotting analysis. To test the role of IL-18 produced by hepatoma cells, FasL expression was examined by flow cytometry after treatment with neutralizing anti-IL-18 antibodies. Further, IL-18 expression was examined in the liver tissues of HBx-transgenic mice. Results: Induction of IL-18 following HBx expression in Chang X-34 and the pattern of IL-18 expression in HBV-integrated cell lines, implicated that HBx transcriptionally induces IL-18 expression. Neutralizing anti-IL-18 antibodies blocked the expression of FasL, suggesting that IL-18 plays a critical role in FasL expression. Further, IL-18 expression in the HBx-transgenic liver, was correlated with the degree of hepatitis. Conclusions: Our results demonstrated that HBx induces IL-18 expression in liver, which may be associated with hepatic injury by amplifying FasL expression during HBV infection. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 380~386 | - |
dc.relation.isPartOf | JOURNAL OF HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Carcinoma, Hepatocellular | - |
dc.subject.MESH | Fas Ligand Protein | - |
dc.subject.MESH | Gene Expression Regulation, Viral | - |
dc.subject.MESH | Hepatitis B virus/physiology* | - |
dc.subject.MESH | Hepatitis B, Chronic/immunology* | - |
dc.subject.MESH | Hepatitis B, Chronic/pathology | - |
dc.subject.MESH | Hepatitis B, Chronic/virology* | - |
dc.subject.MESH | Hepatocytes/immunology | - |
dc.subject.MESH | Hepatocytes/pathology | - |
dc.subject.MESH | Hepatocytes/virology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-18/genetics* | - |
dc.subject.MESH | Interleukin-18/metabolism | - |
dc.subject.MESH | Liver/immunology | - |
dc.subject.MESH | Liver/pathology | - |
dc.subject.MESH | Liver/virology | - |
dc.subject.MESH | Liver Neoplasms | - |
dc.subject.MESH | Membrane Glycoproteins/genetics | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Transgenic | - |
dc.subject.MESH | Trans-Activators/genetics* | - |
dc.subject.MESH | Transcription, Genetic/physiology | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | Hepatitis B virus X protein induced expression of interleukin 18: a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Mi Ock Lee | - |
dc.contributor.googleauthor | Youn Hee Choi | - |
dc.contributor.googleauthor | Eui Cheol Shin | - |
dc.contributor.googleauthor | Hyo Jin Kang | - |
dc.contributor.googleauthor | Young Mee Kim | - |
dc.contributor.googleauthor | Su Yon Jeong | - |
dc.contributor.googleauthor | Je Kyung Seong | - |
dc.contributor.googleauthor | Dae Yeul Yu | - |
dc.contributor.googleauthor | Hyeseong Cho | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | Se Jong Kim | - |
dc.identifier.doi | 10.1016/S0168-8278(02)00181-2 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A01641 | - |
dc.relation.journalcode | J01441 | - |
dc.identifier.eissn | 1600-0641 | - |
dc.identifier.pmid | 12175634 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0168827802001812 | - |
dc.subject.keyword | Hepatitis B virus X protein | - |
dc.subject.keyword | Interleukin 18 | - |
dc.subject.keyword | Fas ligand | - |
dc.subject.keyword | Liver injury | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.alternativeName | Park, Jeon Han | - |
dc.contributor.affiliatedAuthor | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | Park, Jeon Han | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 37 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 380 | - |
dc.citation.endPage | 386 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HEPATOLOGY, Vol.37(3) : 380-386, 2002 | - |
dc.identifier.rimsid | 38311 | - |
dc.type.rims | ART | - |
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