Cited 0 times in
간경변 환자의 문맥압 항진증에 대한 Terlipressin의 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이동기 | - |
dc.date.accessioned | 2016-05-16T10:53:47Z | - |
dc.date.available | 2016-05-16T10:53:47Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143353 | - |
dc.description.abstract | Background/Aims: We conducted this prospective study to evaluate portal hypotensive effect of terlipressin in patients with liver cirrhosis and to find out the factors that contribute to effective reduction of portal pressure after terlipressin administration. Methods: A total of 34 patients with cirrhosis who have experienced variceal bleeding were selected. We measured the mean blood pressure (MBP), heart rate (HR), hepatic venous pressure gradient (HVPG), and portal venous flow (PVF) before and 5, 10, 15, 20 minutes after terlipressin administration. Patients who showed an average HVPG reduction of ≥ 20% from 5 min to 20 min after terlipressin administration were defined as responder. Results: At 5 minutes after terlipressin administration, HVPG and PVF decreased from 17.5±5.5 mmHg to 14.1±4.7 mmHg (-19.4±14.8%, p<0.01) and, from 842.6±386.0 mL/min to 642.5±358.5 mL/min (-25.5±12.2%, p<0.01). Elevation of MBP and reduction of HR started after 5 min (p<0.01) and sustained until 20 min. Twenty six patients (76.5%) were classified as responder. In multivariate analysis to identify factors which affect responder, only the Child-Pugh score was a significantly independent factor for responder (Child-Pugh score < 10, odds ratio 135.3, 95% CI [2.45, 7472.33], p=0.016). Conclusions: Terlipressin might be helpful in control of variceal bleeding due to reducing portal pressure and more effective in cirrhotic patients with a low Child-Pugh score. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 198~203 | - |
dc.language | Korean Journal of Gastroenterology | - |
dc.publisher | Korean Journal of Gastroenterology | - |
dc.relation.isPartOf | Korean Journal of Gastroenterology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 간경변 환자의 문맥압 항진증에 대한 Terlipressin의 효과 | - |
dc.title.alternative | Effect of Terlipressin Administration on Portal Pressure in Patients with Liver Cirrhosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 백순구 | - |
dc.contributor.googleauthor | 김영주 | - |
dc.contributor.googleauthor | 박중화 | - |
dc.contributor.googleauthor | 서정인 | - |
dc.contributor.googleauthor | 정필호 | - |
dc.contributor.googleauthor | 김문영 | - |
dc.contributor.googleauthor | 박동훈 | - |
dc.contributor.googleauthor | 김현수 | - |
dc.contributor.googleauthor | 이동기 | - |
dc.contributor.googleauthor | 권상옥 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02723 | - |
dc.relation.journalcode | J02015 | - |
dc.identifier.eissn | 2233-6869 | - |
dc.subject.keyword | Liver cirrhosis | - |
dc.subject.keyword | Portal hypertension | - |
dc.subject.keyword | Terlipressin | - |
dc.contributor.alternativeName | Lee, Dong Ki | - |
dc.contributor.affiliatedAuthor | Lee, Dong Ki | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 198 | - |
dc.citation.endPage | 203 | - |
dc.identifier.bibliographicCitation | Korean Journal of Gastroenterology, Vol.39(3) : 198-203, 2002 | - |
dc.identifier.rimsid | 53097 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.