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Xenopus oocytes에서 발현된 유전자재조합 세로토닌 제3형 수용체에 대한 한국산 홍삼 사포닌의 효과

Title
Xenopus oocytes에서 발현된 유전자재조합 세로토닌 제3형 수용체에 대한 한국산 홍삼 사포닌의 효과
Other Titles
The Effect of Korean Red Ginseng Saponins on the Recombinant Serotonin Type 3 Receptor Expressed in Xenopus Oocytes
Authors
구본녀;강정완;강정환;민경태;고성룡;김미경;배선준
Issue Date
2001
Journal Title
고려인삼학회지
ISSN
1226-8453
Citation
고려인삼학회지, Vol.25(2) : 74~81, 2001
Abstract
The effect of Korean Ginseng saponins (total saponin, PD saponin and PT saponin) on the serotonin type 3 receptor, which is known to be involved in nausea and vomiting following anticancer chemotherapy or the general anesthesia, was investigated. after in vitro transcribed recombinant serotonin type 3 receptor in the Xenopus laevis oocyte, classic two electrodes voltage clamp technique was used. All of ginseng saponins inhibited the response of the agonist, serotonin, on the serotonin type 3 receptor in a dose-dependent manner. PT saponin showed to have the inhibitory effect more than 2 times as potent as PD saponin. Total saponin shifted the serotonin dose response plot to the right (EC50/, 0.70±0.17 μM into 3.57±1.42 μM, and Hill coefficient, 2.14±0.60 into 1.52±1.00). Ginseng saponin did not change the reversal potential (∼0 mV) of serotonin type 3 receptor. These results suggest that Korean ginseng saponin may have the inhibitory effect on serotonin type 3 receptor.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/142799
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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