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Homeostasis Model Assessment법을 이용한 인슐린저항성 평가의 한계

Title
Homeostasis Model Assessment법을 이용한 인슐린저항성 평가의 한계
Other Titles
Limitation of Validity of Homeostasis Model Assessment as a Index of Insulin Resistance
Authors
윤용석;박석원;허갑범;이현철;김경래;임승길;이종호;차봉수;남수현;남재현;안철우;김오연;박효경;송영득
Issue Date
2000
Journal Title
Journal of Korean Diabetes Association (당뇨병)
ISSN
1015-6461
Citation
Journal of Korean Diabetes Association (당뇨병), Vol.24(5) : 541~551, 2000
Abstract
Background: Homeostasis model assessment of insulin resistance (HOMAIR) had been proposed as a simple and inexpensive alternative to other complex procedures measuring insulin resistance. We evaluated the validity of HOMAIR, comparing to total glucose disposal rate measured by euglycemic clamp test in 63 subjects with normal glucose tolerance, 21 with impaired glucose tolerance and 47 with type 2 DM. Methods: HOMAIR and HOMA cell function (Homeostasis model assessment of cell function) were calculated with formula described by Matthews [HOMAIR: fasting insulin ( U/mL) X fasting glucose (mmol/L) / 22.5, HOMA cell function: 20 X fasting insulin ( U/mL) / (fasting glucose (mmol/L) - 3.5)]. 2-hour euglycemic (5 mmol/L) hyperinsulinemic (717 pmol/L) clamp test were carried out. Results: The strong inverse correlation (r=-0.658, <0.001) was shown between log transformed HOMAIR and total glucose disposal rates. The agreement of two methodes in the categorization according to insulin resistance was moderate (weighed kappa=0.45). The magnitude of correlation coefficients were smaller in subjects with lower BMI (BMI < 23.7 kg/m2, r = -0.441 vs BMI > or = 23.7 kg/m2, r = -0.693, p = 0.0183), lower HOMA cell function (HOMA cell function < 57.2, r = -0.514 vs HOMA cell function > or = 57.2, r = -0.773, p = 0.0091) and higher fasting glucose levels (fasting glucose < 102 mg/dL, r = -0.697 vs fasting glucose > or = 102 mg/dL, r = -0.59, p = 0.0735). The results of correlation analysis was not significant in diabetics with lower BMI. Conclusion: Limitation of validity of HOMAIR should be carefully considered in subjects with lower BMI and lower fasting insulin to glucose levels, such as lean type 2 diabetes with insulin secretory defects.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/142795
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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