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대뇌피질 발달기형이 동반된 소아간질의 임상 및 전기 생리학적 특징에 대한 연구

대뇌피질 발달기형이 동반된 소아간질의 임상 및 전기 생리학적 특징에 대한 연구
Other Titles
Clinical and Electrophysiologic Characteristics of Malformation of Cortical Development with Childhood Epilepsy
Issue Date
Journal Title
Journal of Korean Epilepsy Society (대한간질학회지)
Journal of Korean Epilepsy Society (대한간질학회지), Vol.5(1) : 10~17, 2001
Purpose: To evaluate the clinical and electrophysiological characteristics of malformation of cortical development (MCD) with epilepsy. Method: We studied clinical and electroencephalographic (EEG) features of 54 childhood epilepsy patients with MCD diagnosed by magnetic resonance imaging (MRI) and pathologic examinations. Results: 1) Bilateral diffuse MCD’s were in 5 patients, bilateral focal MCD’s were in 8, unilateral diffuse MCD’s in 7, and unilateral focal MCD’s were noted in 34 patients. 2) Partial seizures were manifested in 35 patients, and 4 of them evolve to infantile spasm (IS), isolated IS was noted in 15 cases, and generalized seizures were noticed in 2 cases 3) Asymmetric EEG backgraound slowing was noted in 30 patients, and 29 patients (96.7%) had MCD’s in abnormal side of brain. 4) Polymorphic slowing was noted in 36 patients, and 28 cases (77.8%) had MCD’s in those area. 5) Sensitivity of partial epileptiform discharges (ED’s) for MCD was 79.6%, but specificity was 68.5%. 6) Localized paroxysmal fast activity was noted in 16 cases (29.6%), and specificity for MCD was 90.7%. 7) Spindle shaped fast activity was noted in 8 patients (14.8%), and its specificity was 100%. 8) Thirty-one cases (57.4%) were intractable to antiepileptic drugs (AED’s). Seventeen cases of them were treated by ketogenic diet, and 12 patients (66.7%) were completely controlled. Among 12 cases of surgical resection, 11 patients (91.7%) became seizure free for 6 months to 2 years. 9) In pathologically confirmed cases, EEG sensitivity for MCD lesion was 100%, but sensitivity of MRI was 69.2%. Conclusion: EEG is most sensitive diagnostic tool for MCD in childhood epilepsy. and many of intractable epilepsy could be controlled by ketogenic diet and surgery.
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1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
Yonsei Authors
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