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Effects of dextromethorphan on nocturnal behavior and brain c-Fos expression in adolescent rats

Title
 Effects of dextromethorphan on nocturnal behavior and brain c-Fos expression in adolescent rats 
Authors
 Jeong Won Jahng ; Tie Yuan Zhang ; Dong Goo Kim ; Seoul Lee 
Issue Date
2001
Journal Title
 European Journal of Pharmacology 
ISSN
 0014-2999 
Citation
 European Journal of Pharmacology, Vol.431(1) : 47~52, 2001 
Abstract
Dextromethorphan, an antitussive widely available over-the-counter, is abused, mostly by teenagers at high doses. In our previous report, a high dose of dextromethorphan activated the midbrain dopamine neurons of adolescent rats. In the present study, we performed c-Fos immunohistochemistry in the dopaminergic terminal regions of adolescent rat brain after the intraperitoneal administration of dextromethorphan at different doses (0, 10, 20, and 40 mg/kg), and also examined the effects on nocturnal behavior. The results showed that dextromethorphan increased c-Fos expression dose dependently in the anterior cingulate cortex, caudate putamen, nucleus accumbens, and central amygdala. Significant ataxia occurred and both locomotor and rearing activity decreased immediately after the dextromethorphan injection. We conclude that the neurons in the reward pathway of the adolescent rat brain appear to be activated by a single injection of dextromethorphan, and that activation of this pathway by dextromethorphan may correlate with the behavioral effects and abuse potential of the drug.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142690
DOI
10.1016/S0014-2999(01)01409-1
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pharmacology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0014299901014091
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