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Receptor-Coupled Contractility of Uterine Smooth Muscle: From Membrane to Myofilaments

Authors
 Y.-H. Lee ; M.-K. Hwang ; Michael J. Taggart ; K. G. Morgan 
Citation
 Experimental Physiology, Vol.86(2) : 283~288, 2001 
Journal Title
 Experimental Physiology 
ISSN
 0958-0670 
Issue Date
2001
Abstract
A comprehensive understanding of the mechanisms by which agonists control uterine contraction is essential for the successful clinical management of parturition and for the timely treatment of situations involving inappropriate uterine performance. In this review we discuss some of the key stimulatory mechanisms linking receptor occupation at the myometrial plasma membrane with alteration of myofilament activation. We focus on evidence that receptor-induced membranous recruitment of the small G-protein rhoA, and its downstream effector rho-associated kinase (ROK) is crucial to agonist-induced Ca2+-sensitisation of uterine contraction and that co-ordination of this signal transduction pathway may be mediated by the actions of caveolins, proteins integral to specialised membranous regions termed caveolae.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142673
DOI
10.1113/eph8602184
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
Yonsei Authors
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