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2형 당뇨병 환자에서 복부(대사성)비만에 따른 죽상경화증의 정도 및 위험요소

Title
2형 당뇨병 환자에서 복부(대사성)비만에 따른 죽상경화증의 정도 및 위험요소
Other Titles
Atherosclerotic Severity and Risk Factors in Type 2 Diabetic Patients with Visceral(Metabolic) Obesity in Korea
Authors
남재현;박석원;이현철;김경래;인승길;송영득;안철우
Issue Date
2001
Journal Title
Korean Diabetes Journal (당뇨병)
ISSN
1015-6461
Citation
Korean Diabetes Journal (당뇨병), Vol.25(1) : 20~34, 2001
Abstract
Background: Type 2 diabetes with hypertension and dyslipidemia are frequently associated with metabolic obesity. It is proposed that such individuals might be characterized by increased insulin resistance and visceral fat, and that macrovascular complications might be more common in these individuals. Thereofer, the aim of this study was to investigate the atherosclerotic severity and risk factors in type 2 diabetic patients with metabolic obesity (MO) in Korea, Methods: Coronary artery calcification (CAC) score, intima-media thickness (IMT) of common carotid artery, and ankle-brachial pressure index (ABPI) were measured. Insulin sensitivity index (ISI) was also measured by the plasma glucose disappearance rate (kitt: %/min). Results: 1. Among 530 type 2 diabetes mellitus (DM) patients, the percent of under-weight (UW), normal-weight (NW), over-weight (OW) and obese (OB) (BMI< 20, 20-25, 25-29,9 and >30, respectively) were 8.9%, 62,1%, 25.1% and 3.9%, respectively. Waist-hip ratio and systolic blood pressure (sBP) were significantly different among the groups according to BMI. Serum triglyceride (TG), HDL-C, free fatty acid (fFA), fibrinogen and fasting c-peptide were significantly different among the groups, The percents of patients with insulin resistance in UW, NW, OW and OB groups were 28%, 60%, 68% and 75%, respectively. The visceral fat area/subcutaneous fat area ratio and visceral fat area/thigh muscle area ratio were significantly increased according to ISI. 2. The patients with MO have above the median values of WHR (0.95 in men and 0.91 in women). sBP, TG, HDL-C, fFA, fibrinogen and ISI were significantly different between the patients with MO and the patients without MO. 3. In OW group as well as NW group, carotid IMT, ABPI and CAC score were significantly different between the patients with MO and the patients without MO. However, these were not different between NW group and OW group. Conclusion: In conclusion, this study suggest that patients with MO have more advanced atherosclerosis and aggravated risk profiles for atherosclerosis than those without MO, regardless of BMI
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/142586
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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