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Y-Chromosome multiplexes and their potential for the DNA profiling of Koreans

Title
Y-Chromosome multiplexes and their potential for the DNA profiling of Koreans
Authors
D. J. Shin;H. J. Jin;W. Kim;S. K. Choi;P. W. Kang;M. S. Han;J. W. Choi;K. D. Kwak
Issue Date
2001
Journal Title
International Journal of Legal Medicine
ISSN
0937-9827
Citation
International Journal of Legal Medicine, Vol.115(2) : 109~117, 2001
Abstract
We have developed four multiplex genotyping systems (GeneKin Y-STR multiplexes) using silver staining with allelic ladders for ten Y-chromosome STR markers (DYS19, DYS385, DYS388, DYS389I/II, DYS390, DYS391, DYS392, DYS393 and DXYS156Y), with a view towards the application of rapid and simple genotyping assay methods for DNA profiling. The GeneKin Y-STR multiplexes developed have followed the published nomenclature and ISFG guidelines for STR analysis. Allele and haplotype frequencies at these Y-STRs loci were analysed by PCR amplification using the GeneKin Y-STR multiplexes, followed by denaturing polyacrylamide gel electrophoresis in 316 unrelated males in the Korean population. A total of 295 different haplotypes were found, 279 of them being unique. Gene diversity ranged from 0.4026 at DYS391 to 0.9606 at DYS385. The haplotype diversity value (which is the same as the discrimination index) calculated from all ten loci combined was 0.9995, which is informative. Our results revealed that a set of ten Y-STRs can discriminate between most of the male individuals in the Korean population (discrimination capacity: 93.35%). The Y-STR multiplexes thus provide useful information for forensic analysis and paternity tests and can also be of great benefit for providing information not normally available from autosomal DNA systems.
URI
http://link.springer.com/article/10.1007/s004140100248

http://ir.ymlib.yonsei.ac.kr/handle/22282913/142584
DOI
10.1007/s004140100248
Appears in Collections:
1. 연구논문 > 5. Research Institutes > 생체방어연구센터
Yonsei Authors
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