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Neonatal intensive care unit outbreak caused by a strain of Klebsiella oxytoca resistant to aztreonam due to overproduction of chromosomal β-lactamase

Title
Neonatal intensive care unit outbreak caused by a strain of Klebsiella oxytoca resistant to aztreonam due to overproduction of chromosomal β-lactamase
Authors
S.H. Jeong;W.M. Kim;J.Y. Ku;I.G. Woo;H.K. Chung;Y.W. Baek;H.Y. Hwang;Y. Chong;K. Lee;J.M. Kim;C.L. Chang
Issue Date
2001
Journal Title
Journal of Hospital Infection
ISSN
0195-6701
Citation
Journal of Hospital Infection, Vol.48(4) : 281~288, 2001
Abstract
Klebsiella oxytoca strains resistant to both aztreonam and ceftriaxone were isolated from six neonates in a neonatal intensive care unit and water reservoirs of two humidifiers attached to the neonatal incubators. These isolates were assumed to be of the same clone because they were characterized by the same antimicrobial susceptibility and pulsed field gel electrophoresis patterns. It was established that the drug resistance was attributed to overproduction of chromosomally encoded Kl β-lactamase. It was determined that an isolate (K. oxytoca H1) contained a high enzyme concentration (27mg/100mg of protein in enzyme extracts), at least 27 times higher than the control K. oxytoca N1. It was also demonstrated that isolates had a point mutation in the — 35 concensus region of the promotor gene ofblaOXY-2 leading to enzyme overproduction. Outbreaks caused by K1 hyperproducers have not previously been described.
URI
http://www.sciencedirect.com/science/article/pii/S0195670101910187

http://ir.ymlib.yonsei.ac.kr/handle/22282913/142455
DOI
10.1053/jhin.2001.1018
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
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