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모야모야병에서 염기성 섬모 세포 성장 인자의 역할

Title
모야모야병에서 염기성 섬모 세포 성장 인자의 역할
Other Titles
The role of basic fibroblast growth factor in moyamoya disease
Authors
김동석;최중언;김현숙;양국희;김세혁
Issue Date
2001
Journal Title
Journal of Korean Neurosurgical Society (대한신경외과학회지)
ISSN
2005-3711
Citation
Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.30(1) : 5~11, 2001
Abstract
Objectives and Importance:The present study investigated the levels of basic fibroblast growth factor(bFGF) in the CSF of patients with moyamoya disease and its clinical significance. Methods:The levels of bFGF in CSF, taken from 26 hemispheres of 14 moyamoya patients and 20 patients without vascular anomaly(control group), were measured by an enzyme-linked immunosorbent assay. We analyzed the correlation between the level of bFGF and the clinical factors such as age, onset pattern, development of neovascularization, and cerebral circulation. Results:The CSF of moyamoya patients contained a high concentration of bFGF to a significant extent. The bFGF level was apparently elevated in the patients in whom neovascularization from indirect revascularization, such as modified encephalo-duro-arterio-synangiosis(EDAS) was well developed. A linear correlation between the values of bFGF and clinical progression was noted. Conclusions:The elevation of bFGF in moyamoya disease seems to be specific. Clinically, the bFGF level may be considered a useful indicator to predict the efficacy of indirect revascularization.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/142408
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Neurosurgery
Yonsei Authors
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